Actively Recruiting
Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
Led by Ashkan Eftekhari · Updated on 2025-06-18
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of cardiac resynchronization therapy (CRT) in patients with symptomatic heart failure who have a low left ventricular ejection fraction (LVEF of 35% or less) and left bundle branch block (LBBB). About one-third of patients receiving CRT do not show improvement, and this study aims to understand how CRT affects coronary blood flow in the left anterior descending artery (LAD) in patients with non-ischemic dilated cardiomyopathy and LBBB. The study hypothesizes that CRT improves heart function not only by resynchronizing the heart's contractions but also by enhancing blood flow in coronary arteries. The study will enroll 60 patients with heart failure caused by non-ischemic dilated cardiomyopathy and LBBB, some with CRT devices and some without. Researchers will measure absolute coronary flow and resistance in the LAD using invasive procedures, including fractional flow reserve (FFR), with CRT devices turned on and off to compare effects. These measurements will help evaluate how CRT influences blood flow and heart muscle work. Participants will undergo invasive flow measurements during the study procedure to assess coronary blood flow and heart function. Researchers will closely monitor absolute coronary flow during the procedure to understand the impact of CRT. The study is conducted at an outpatient cardiology clinic and involves assessing heart rhythm, medical therapy stability, and other heart health factors. The total duration and follow-up details are not specified, but the focus is on real-time measurements during the procedure.
CONDITIONS
Brief Title
Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- QRS duration of 150 milliseconds or more before CRT implantation
- Heart failure due to dilated cardiomyopathy
- Sinus rhythm
- Stable medical therapy for heart failure
- Presence of left bundle branch block (LBBB)
- Having a cardiac resynchronization therapy (CRT) device
You will not qualify if you...
- Estimated glomerular filtration rate (eGFR) less than 30 ml/min
- Severe valvular heart disease
- Permanent atrial fibrillation or atrial flutter
- Prior percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
- Prior myocardial infarction
- Heart failure caused by ischemic heart disease
- Presence of other devices such as pacemakers or implantable cardioverter defibrillators (ICD)
- Inability to provide informed consent
- Inability to understand Danish language
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo measurement of absolute coronary flow and resistance during a cardiac procedure.
1 procedure visit (in-person)
Trial Site Locations
Total: 1 location
1
Aalborg Universityhospital
Aalborg, Denmark, 9000
Actively Recruiting
Research Team
A
Ashkan Eftekhari
S
Sanna Gunnarstein
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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