Eosinophil Activation and Function in Parasitic Infections and Other Conditions With Increased Tissue or Peripheral Blood Eosinophilia in Humans

What this Trial Is About

Researchers are studying how eosinophils, a type of white blood cell, become activated and their role in immune reactions. Eosinophils often increase with allergies, asthma, parasitic infections, some autoimmune diseases, and rarely tumors, a condition called eosinophilia. While usually without symptoms, eosinophilia can sometimes cause swelling, itching, lung problems, heart disease, or nerve damage due to toxic substances released by these cells. Participants with eosinophil counts above 750/ml or abnormal eosinophil buildup in tissues or skin will have thorough medical exams, blood tests, and possibly additional tests based on age and symptoms. This observational study does not offer experimental treatments but monitors clinical responses and collects blood, bone marrow, tissue, and fluid samples for research. Follow-up includes yearly evaluations and may involve bone marrow biopsies, genetic testing, and leukapheresis for adults. Participants will be involved in detailed clinical evaluations at baseline and annually, with sample collections to study disease mechanisms and immune responses. The study aims to identify causes, biomarkers, and treatment effects on eosinophils. Safety monitoring includes standard care for those needing treatment, while research focuses on immune cell behavior, genetic factors, and long-term effects. Participation duration varies per individual, with ongoing assessments of disease activity and patient-reported outcomes.

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia