Study on Advanced Glycation End-products Accumulation in Adults and Children Starting Long-Term Parenteral Nutrition Using Non-Invasive Skin Measurements

What this Trial Is About

Researchers are evaluating the buildup of advanced glycation end-products AGEs in adults and children who are beginning long-term parenteral nutrition, a treatment where nutrition is given intravenously. AGEs form in the body through non-enzymatic reactions and tend to accumulate with age, high blood sugar, and oxidative stress. This accumulation can lead to metabolic and cardiovascular problems, and preliminary data suggest that patients receiving long-term intravenous nutrition may have increased AGE levels due to high glucose exposure. The study involves non-invasive skin measurements of AGE levels using a specialized device at the start, 6 months, and 12 months. Samples from the parenteral nutrition bags will be collected and analyzed for AGE content. Participants will be monitored during their routine hospital consultations every 6 months, where metabolic blood tests and nutritional data including 3-day dietary records will also be collected and analyzed. Participants will be involved for 12 months, with skin AGE measurements and metabolic assessments at three main time points. Researchers will analyze skin AGE levels, metabolic and cardiovascular status, and risk factors over time. The study includes collecting and freezing nutrition bag samples for central analysis, and monitoring glucose levels using a holter device. This comprehensive follow-up aims to understand AGE accumulation in patients on long-term parenteral nutrition.

AGE Accumulation in Patients on Long-term Parenteral Nutrition