What is AI-guided cognitive behavioral therapy studying for depression and anxiety?

This clinical trial is studying how AI-guided cognitive behavioral therapy (CBT) may affect symptoms of mild depression and anxiety disorders. Researchers want to see if using AI to guide therapy sessions delivered digitally can improve mental health care access and outcomes. The study is led by Aleksandra Stojanovic and aims to better understand AI's role in psychotherapy.

Who may be eligible for this depression and anxiety clinical trial?

Adults aged 18 and older diagnosed with mild depression or anxiety disorders may be eligible. Participants must be able to consent, have access to a device to use the digital therapy, and be willing to attend weekly sessions over 10 weeks. People with severe mental health conditions or currently in other psychotherapy programs are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this depression and anxiety clinical trial?

Study-related care, including the AI-guided therapy or standard psychiatric care and all trial visits, is provided at no cost. However, personal travel expenses to attend sessions or assessments may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel costs.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

ID07576686

Evaluating AI-Guided Cognitive Behavioral Therapy for Adults With Mild Depression and Anxiety Disorders

Led by Aleksandra Stojanovic · Updated on 2026-05-08

120

Participants Needed

Research Sites

3 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the effectiveness of an artificial intelligence AI-guided cognitive behavioral therapy CBT program for adults with mild depression and anxiety disorders. These mental health conditions are widespread and burdensome, yet access to psychotherapy is limited. This controlled clinical trial aims to compare AI-guided CBT with standard psychiatric care to explore how AI might improve access to and delivery of mental health treatment. Participants will be assigned to one of two groups an experimental group receiving AI-guided CBT through a digital platform, and a control group receiving standard psychiatric care. The AI-guided CBT involves structured weekly sessions lasting 45 to 60 minutes over 10 weeks, conducted under clinical supervision. The control group will receive routine clinical monitoring and treatment as determined by their clinician without access to the AI intervention. During the study, participants will undergo assessments at the start, mid-treatment week 5, and after treatment completion week 10. Researchers will measure changes in depression and anxiety symptoms, perceived stress, social support, digital therapeutic alliance, and overall clinical improvement. Data collection involves standardized scales and clinical impression assessments. Participants will provide informed consent, and data will be handled following ethical and privacy standards.

CONDITIONS

Brief Title

AI-Guided CBT for Depression and Anxiety

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age 18 years or older
Diagnosis of mild depressive disorder and/or anxiety disorder confirmed by a structured clinical interview (MINI)
Ability to understand and provide informed consent
Access to a device capable of using the digital platform (computer, tablet, or smartphone)
Willingness to participate in weekly sessions over a 10-week period

You will not qualify if you...

Moderate to severe depressive disorder
Current or past diagnosis of psychotic disorder
Bipolar disorder
Substance use disorder or dependence
Primary diagnosis of antisocial personality disorder
Severe cognitive impairment or inability to use digital tools
Acute suicidal risk requiring immediate intervention
Concurrent participation in another structured psychotherapy program

Research Team

Aleksandra Stojanovic, MD, PhD Candidate

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Evaluating AI-Guided Cognitive Behavioral Therapy for Adults With Mild Depression and Anxiety Disorders

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria