Individual Positive End-expiratory Pressure Settings Optimize Intraoperative Mechanical Ventilation and Reduce Postoperative Atelectasis.
Sérgio M Pereira, Mauro R Tucci, Caio C A Morais...
https://pubmed.ncbi.nlm.nih.gov/30260897Actively Recruiting
Age: 18Years +
FEMALE
ID06619626
The Effect of Alveolar Recruitment on Perioperative Outcomes in Obese Patients in Major Gynaecological Cancer Surgery: a Prospective Randomised Controlled Trial
Led by Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Updated on 2024-10-09
40
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effect of alveolar recruitment strategy on postoperative lung complications in obese patients undergoing major open gynecological cancer surgeries. This study focuses on patients with endometrial or ovarian cancer who receive lung protective ventilation during surgery. The research also aims to assess intraoperative blood flow, breathing mechanics, and length of hospital stay after surgery. Participants will be divided into two groups: one group will receive lung protective ventilation combined with alveolar recruitment strategy, and the other group will receive lung protective ventilation without alveolar recruitment. The alveolar recruitment maneuver involves adjusting ventilator settings to increase positive pressure in the lungs during surgery to potentially improve breathing. Ventilation settings include tidal volume based on ideal body weight and positive end-expiratory pressure. During the study, patients will be monitored closely for lung complications within 24 hours after surgery. Researchers will also track blood pressure and breathing parameters during the operation. The length of hospital stay will be recorded to assess recovery. This trial provides detailed monitoring of respiratory and hemodynamic function during and after surgery to understand the effects of the recruitment strategy.
CONDITIONS
Brief Title
Alveolar Recruitment in Obese Patients in Major Gynaecological Cancer Surgery
Who Can Participate
Age: 18Years +
FEMALE
Eligibility Criteria
You may qualify if you...
- Patients with ASA II or III physical status
- Body mass index (BMI) greater than 30 kg/m2 and less than 40 kg/m2
- Patients with an ARISCAT risk score between 26 and 44
You will not qualify if you...
- Patients with an ARISCAT risk score greater than 44
- Patients with a body mass index (BMI) greater than 40 kg/m2
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Surgery day
Participants undergo major open gynaecological cancer surgery with lung protective ventilation. Some participants receive an alveolar recruitment strategy during mechanical ventilation, while others receive ventilation without this strategy.
1 visit (in-person)
Post-operative Follow-up
Duration - 24 hours postoperatively
Participants are monitored for postoperative pulmonary complications and perioperative haemodynamics following surgery.
1 follow-up visit (in-person) within 24 hours after surgery
Trial Site Locations
Total: 1 location
1
Duygu Akyol
Istanbul, Turkey (Türkiye)
Actively Recruiting
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Research Team
D
Duygu Akyol
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Perioperative lung-protective ventilation strategy reduces postoperative pulmonary complications in patients undergoing thoracic and major abdominal surgery.
Sang-Heon Park
https://pubmed.ncbi.nlm.nih.gov/26885294Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial.
P M Spieth, A Güldner, C Uhlig...
https://pubmed.ncbi.nlm.nih.gov/29452815