Actively Recruiting
Study of Methylomic Features and Risk Prediction for Hepatitis B-related Acute-on-Chronic Liver Failure
Led by Qilu Hospital of Shandong University · Updated on 2025-12-10
100
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What This Trial Is About
Researchers are studying the methylomic characteristics of patients with hepatitis B-related acute-on-chronic liver failure to develop and validate a risk prediction model that can help guide clinical decisions and improve patient outcomes. This observational study will create a methylomics-based classifier to assist in disease prognosis and clinical assessment, aiming to enhance the diagnostic process for liver failure. The study involves patients with chronic hepatitis B, hepatitis B-related liver cirrhosis, and hepatitis B-related acute-on-chronic liver failure. Participants will be observed over a period of up to 48 months, during which their methylomic features will be analyzed to support the development of the prognostic model. Participants will undergo laboratory tests including measurements of serum total bilirubin and coagulation parameters to assess liver function. The main outcome measured is the analysis of methylomic features related to hepatitis B-related acute-on-chronic liver failure. The study will monitor participants clinical data to validate the prognostic risk prediction model, with the overall study duration extending to the end of 2026.
CONDITIONS
Brief Title
Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure
Research Team
Y
Yu-Chen Fan
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
