Actively Recruiting
Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure
Led by Qilu Hospital of Shandong University · Updated on 2025-12-10
100
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the methylomic features of patients with hepatitis B-related acute-on-chronic liver failure and establish and validate a prognostic risk prediction classification model. The findings are of significant importance for guiding clinical practice and improving patient prognosis. Additionally, a methylomics-based classifier model for liver failure will be developed for disease prognosis analysis and clinical assessment, with the potential to enhance the diagnostic efficiency of liver failure.
CONDITIONS
Official Title
Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic hepatitis B defined as persistent hepatitis B surface antigen (HBsAg) positive for over six months
- Diagnosis of hepatitis B-related liver cirrhosis based on histology, ultrasound or imaging, endoscopy, or clinical history
- Diagnosis of hepatitis B-related acute-on-chronic liver failure according to 2018 Asia-Pacific clinical guidelines
- Laboratory criteria for liver failure including jaundice (serum total bilirubin 85 mol/L) and coagulopathy (INR 1.5 or prothrombin activity <40%)
You will not qualify if you...
- Co-infection with other hepatitis viruses
- History of hepatocellular carcinoma or other malignancies
- Concomitant autoimmune liver disease
- Insufficient clinical data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Actively Recruiting
Research Team
Y
Yu-Chen Fan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here