Actively Recruiting
Analysis of the Pathophysiological and Functional State of the Knee Joint
Led by Istituto Ortopedico Rizzoli · Updated on 2025-07-17
25
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis is a common degenerative condition that affects the knee joint, causing pain and reduced function that worsens over time. It impacts both older and younger adults, sometimes due to injury. This research aims to better understand osteoarthritis onset and progression by improving diagnostic and prognostic methods, as current treatments mainly focus on managing symptoms rather than addressing underlying causes. The study evaluates the use of Magnetic Resonance Imaging (MRI) and gait analysis to examine the knee joint's condition and function. MRI will provide detailed images of joint tissues, while gait analysis, combined with sensor data and musculoskeletal models, will assess joint forces and movements during walking. These diagnostic tests will be conducted at the start of the study and again after 12 months to observe any changes. Participants will undergo MRI scans, strength tests using a manual dynamometer, bioimpedance analysis, gait analysis including electromyography, and complete clinical questionnaires at both baseline and 12-month follow-up visits. Researchers will monitor these assessments to understand joint health and function over time. The study does not involve any treatment but focuses on diagnostic evaluation, lasting at least one year for each participant.
CONDITIONS
Brief Title
Analysis of the Pathophysiological and Functional State of the Knee Joint
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Knee pain and/or loss of functionality
- Kellgren-Lawrence grade less than or equal to 2
- Arthroscopic evidence of cartilage tissue lesions
- Evidence of cartilage and/or meniscal tissue degeneration and/or subchondral bone marrow lesions
- Age between 18 and 60 years
You will not qualify if you...
- History or evidence of previous partial or total knee prosthesis interventions
- Inability to provide informed consent
- Conditions or physical disorders incompatible with the use of MRI and electrical stimulation, such as implanted active or passive biomedical devices, epilepsy, or severe venous insufficiency in the lower limbs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline and 12-month follow-up
Participants undergo gait analysis and magnetic resonance imaging to assess the functionality and pathological condition of the knee.
2 visits (in-person)
Duration - 12 months
Participants are monitored through strength measurements, bioimpedance analysis, gait analysis including electromyography, and clinical questionnaires at baseline and 12 months to evaluate knee function over time.
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
IRCCS Istituto Ortopedico Rizzoli
Bologna, Italy, 40136
Actively Recruiting
Research Team
S
stefano zaffagnini
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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