Study of Knee Joint Function and Degeneration Using MRI and Gait Analysis for Osteoarthritis Diagnosis

What this Trial Is About

Osteoarthritis is a common degenerative condition affecting the knee joint, impacting about 7% of the global population and approximately 3.9 million people in Italy. It causes pain and decreased function, limiting knee movement and affecting both older and younger individuals due to trauma. Current treatments mainly address symptoms, so this study aims to improve diagnostic and prognostic methods to better understand the diseases onset and progression. The study evaluates the use of Magnetic Resonance Imaging MRI and gait analysis to assess the knee joints pathophysiological and functional state. MRI provides detailed images of joint morphology, structure, and tissue composition, while gait analysis measures joint function and forces during movement using sensors and musculoskeletal models based on MRI data. These diagnostic tests are used at the start of the study and again after 12 months. Participants will undergo MRI scans, gait analysis including electromyography, strength measurements with a dynamometer, bioimpedance analysis, and clinical questionnaires at baseline and after 12 months. Researchers will monitor changes in joint condition and function over time to gain insights into osteoarthritis progression. The study runs from July 2025 to April 2027, with assessments spaced across this period to track disease impact.

Analysis of the Pathophysiological and Functional State of the Knee Joint