Analysis of Synovial Fluid, Bone and Articular Cartilage From Osteoarthritic Thumb Basal Joints in Relation to Metabolic Risk Factors and Hand Function

What this Trial Is About

This research focuses on patients with osteoarthritis in the thumb basal joint who are scheduled for trapeziectomy surgery. The study aims to examine molecular markers in the synovial fluid, bone, and cartilage from these osteoarthritic joints. It also investigates the breakdown of extracellular matrix proteins in the thumb basal joints and compares these findings with similar degradations in knee joints affected by osteoarthritis. Additionally, the study explores links between the metabolic profile of patients and joint degradation, along with patient-reported hand function, pain, strength, and thumb motion range. During the study, synovial fluid is collected from the thumb basal joint before surgery, and bone and cartilage samples are harvested during the operation. Blood samples are taken to assess lipid profiles and glucose intolerance. Participants undergo measurements of blood pressure, obesity, grip strength, pinch strength, and thumb range of motion. These assessments occur at the start of the study and one year after surgery. Patients also complete questionnaires about hand function and pain levels. Participants are involved in physical examinations and provide biological samples for analysis. Researchers measure serum cholesterol levels at baseline and evaluate patient-reported outcomes using the QuickDASH and numeric rating scale for pain. The study monitors changes in hand strength, motion, and symptoms over time, emphasizing the relationship between metabolic factors and joint health. The overall study duration includes baseline evaluations and a follow-up one year after surgery to assess recovery and joint function.

Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints