Study of Risk Factors and Outcomes of Anastomotic Leakage After Colorectal Surgery

What this Trial Is About

This research aims to identify and measure independent risk factors for anastomotic leakage AL, a serious complication following colorectal surgery, with rates ranging from 2% to 30%. The study will assess ALs incidence and its impact on patient outcomes, using criteria from the International Study Group of Rectal Cancer. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled over one year in a single-center, prospective observational study to reduce variability. Participants will undergo elective or emergency colorectal surgery with primary anastomosis, including ileocolic, colocolic, colorectal, or coloanal types. The study will monitor risk factors before, during, and after surgery, including demographic data, comorbidities, surgical details, and postoperative management. AL will be defined and graded by severity from mild without treatment to severe requiring reoperation. The study will also analyze inflammatory markers in serum and drain fluid to detect leaks early. During the study, researchers will collect data from medical records, surgical notes, and follow-up visits. They will evaluate outcomes such as AL incidence within 30 days post-surgery, severity, reoperation, readmission, hospital stay length, mortality, and the need for permanent stoma within 90 days. Statistical analysis will develop and validate predictive models for AL risk. The study follows ethical standards and requires informed consent from participants.

Anastomotic Leakage After Colorectal Surgery.