Surgery Study Comparing Anatomical vs. Non-Anatomical Liver Removal in Patients With RAS-Mutated Colorectal Cancer Liver Metastases

What this Trial Is About

Researchers are studying patients with colorectal liver metastases CRLM that have a mutation in the RAS gene. The trial aims to compare two surgical methods anatomical resection removal of the entire liver segment containing the tumor versus non-anatomical resection removal of the tumor with some healthy liver tissue, regardless of liver segments. This is the first prospective, randomized trial to evaluate the safety and effectiveness of using molecular information to guide surgery for this condition. Participants will be randomly assigned to one of two groups one undergoing anatomical resection and the other undergoing non-anatomical resection. These surgeries will be performed at specialized centers experienced in liver surgery. The study includes 220 patients and aims to see if the anatomical approach leads to better long-term outcomes compared to the non-anatomical approach. During the study, participants will be closely monitored for intrahepatic disease-free survival over 24 months. Researchers will also assess surgery-related factors such as blood loss, operating time, hospital and intensive care stays, complications, and liver function tests before and after surgery. Quality of life will be measured at 12 months. Safety and survival outcomes will be tracked up to 24 months to provide a complete view of both surgical methods.

Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer