Actively Recruiting
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
Led by Technische Universität Dresden · Updated on 2024-06-13
240
Participants Needed
37
Research Sites
360 weeks
Total Duration
On this page
Sponsors
T
Technische Universität Dresden
Lead Sponsor
G
German Cancer Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
the ARMANI trial will test the hypothesis, if an anatomic resection (AR) improves long-term outcome vs. a non-anatomical resection (NAR) in patients undergoing surgery for RAS-mutated colorectal liver metastasis (CRLM).
CONDITIONS
Official Title
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Colorectal cancer with RAS mutation (KRAS or NRAS)
- Colorectal liver metastases (single or multiple)
- Planned complete (R0) resection of liver metastases (and primary tumor, if present)
- Both anatomical and non-anatomical liver resections are technically feasible
- Male or female patients aged 18 years or older
- Written informed consent provided
You will not qualify if you...
- Presence of metastases outside the liver
- Planned staged liver resection (e.g., two-stage hepatectomy)
- Diagnosis of another cancer within 5 years prior to randomization, except curatively treated in situ cervical cancer or curatively resected non-melanoma skin cancer
- Expected lack of compliance
- Addiction or other illnesses preventing understanding of the clinical trial and its possible consequences
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Department of Surgery at the University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
Mannheim, Baden-Wurttemberg, Germany, 68167
Actively Recruiting
2
Department of Gastrointestinal-, Thoracic and Vascular Surgery University Hospital Carl Gustav Carus Technische Universität Dresden
Dresden, Saxony, Germany, 01307
Actively Recruiting
3
Intestinal Center West Middle Franconia, ANregiomed Clinic Ansbach
Ansbach, Germany
Actively Recruiting
4
Clinic for General, Vizeral and Transplant Surgery, Augsburg University Hospital
Augsburg, Germany
Actively Recruiting
5
Department of General, Visceral and Vascular Surgery, Charité, University Medicine Berlin, Campus Benjamin Franklin Berlin
Berlin, Germany
Actively Recruiting
6
Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn
Bonn, Germany
Actively Recruiting
7
Surgical Clinic, Municipal Hospital Braunschweig gGmbH
Braunschweig, Germany
Actively Recruiting
8
Cancer Center, Helios Amper-Hospital Dachau
Dachau, Germany
Actively Recruiting
9
Surgical Clinic, Dortmund Hospital
Dortmund, Germany
Actively Recruiting
10
Clinic for General and Visceral Surgery, Municipal Hospital Dresden
Dresden, Germany
Actively Recruiting
11
Clinic for General, Visceral and Pediatric Surgery, University Hospital Düsseldorf
Düsseldorf, Germany
Actively Recruiting
12
Surgical Clinic, University Hospital Erlangen
Erlangen, Germany
Actively Recruiting
13
Clinic for General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe University Frankfurt am Main
Frankfurt, Germany
Actively Recruiting
14
Department for General and Visceral Surgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg
Freiburg im Breisgau, Germany
Actively Recruiting
15
JLU Gießen, Department for General, Visceral, Thoracic and Transplant Surgery
Giessen, Germany
Actively Recruiting
16
Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg-August-University
Göttingen, Germany
Actively Recruiting
17
Clinic and Polyclinic for General Surgery, Department of Gastrointestinal, Thoracic and Vascular Surgery, University Greifswald, University Hospital Greifswald
Greifswald, Germany
Actively Recruiting
18
University Hospital and Polyclinic for Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale)
Halle, Germany
Actively Recruiting
19
Center for Surgical Medicine - Clinic and Polyclinic for General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf
Hamburg, Germany
Actively Recruiting
20
Department of Liver, Bile Duct and Pancreas Surgery, University Department of surgery, Asklepios Klinik Barmbek
Hamburg, Germany
Actively Recruiting
21
Clinic for General, Visceral and Minimally Invasive Surgery, KRH Clinic Siloah, Hannover
Hanover, Germany
Actively Recruiting
22
Medizinische Hochschule Hannover, Department of General, Visceral and Transplant Surgery
Hanover, Germany
Actively Recruiting
23
Department of General, Visceral and Transplantation Surgery, University of Heidelberg
Heidelberg, Germany
Actively Recruiting
24
General Visceral and Vascular Surgery, Jena University Medical Center
Jena, Germany
Actively Recruiting
25
Clinic for Surgery, University Hospital Schleswig-Holstein Lübeck Campus
Lübeck, Germany
Actively Recruiting
26
University Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine, Otto von Guericke University Magdeburg
Magdeburg, Germany
Actively Recruiting
27
Clinic for General, Visceral and Transplantation Surgery, University Medical Center of the Johannes Gutenberg-University Mainz
Mainz, Germany
Actively Recruiting
28
Clinic for Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg
Marburg, Germany
Actively Recruiting
29
LMU Munich Hospital, Clinic for General, Visceral and Transplant Surgery
Munich, Germany
Actively Recruiting
30
Department Hepato-Pancreato-Biliary Surgery, Barmherzige Brüder gGmbH of the Hospital Barmherzige Brüder Munich
München, Germany
Actively Recruiting
31
Department of Surgery, University Hospital rechts der Isar
München, Germany
Actively Recruiting
32
Clinic for General, Visceral and Transplant Surgery, University of Münster
Münster, Germany
Actively Recruiting
33
University Hospital for General and Visceral Surgery, Oldenburg Hospital
Oldenburg, Germany
Withdrawn
34
Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center
Tübingen, Germany
Actively Recruiting
35
Clinic for General and Visceral Surgery, Ulm University Medical Center
Ulm, Germany
Actively Recruiting
36
General and Visceral Surgery, Helios University Medical Center Wuppertal, University Witten/Herdecke
Wuppertal, Germany
Actively Recruiting
37
Department for General, Visceral, Transplant, Vascular and Pediatric Surgery, Julius-Maximilian-University Würzburg, University Hospital Würzburg
Würzburg, Germany
Actively Recruiting
Research Team
J
Jürgen Weitz, Prof Dr med
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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