The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.
S L Morgan, J E Baggott, W H Vaughn...
https://pubmed.ncbi.nlm.nih.gov/2405864Completed
Phase 2
Age: 18Years - 85Years
All Genders
ID00000395
Mechanisms of Antifolate Efficacy in Arthritis
Led by University of Alabama at Birmingham · Updated on 2016-12-16
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
CONDITIONS
Official Title
Antifolate Effectiveness in Arthritis
Who Can Participate
Age: 18Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Individuals starting methotrexate for rheumatoid arthritis.
- Study subjects should not currently be taking folic acid-containing vitamins.
You will not qualify if you...
- Cancer, renal, or liver disease.
- Previous use of methotrexate within the past 6 months or current use of folic acid-containing supplements.
Trial Site Locations
Total: 1 location
1
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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Published Research Related To This Trial
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
S L Morgan, J E Baggott, H Refsum...
https://pubmed.ncbi.nlm.nih.gov/1934868Dietary intake and circulating vitamin levels of rheumatoid arthritis patients treated with methotrexate.
S L Morgan, R J Hine, W H Vaughn...
https://pubmed.ncbi.nlm.nih.gov/8443257Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial.
S L Morgan, J E Baggott, W H Vaughn...
https://pubmed.ncbi.nlm.nih.gov/7978695Nutrient intake patterns, body mass index, and vitamin levels in patients with rheumatoid arthritis.
S L Morgan, A M Anderson, S M Hood...
https://pubmed.ncbi.nlm.nih.gov/9313385Methotrexate in rheumatoid arthritis: folate supplementation should always be given.
S L Morgan, J E Baggott, G S Alarcón
https://pubmed.ncbi.nlm.nih.gov/18020507Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
S L Morgan, J E Baggott, J Y Lee...
https://pubmed.ncbi.nlm.nih.gov/9517760The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
J E Baggott, S L Morgan, W J Koopman
https://pubmed.ncbi.nlm.nih.gov/9704638Folic acid supplementation and methotrexate efficacy: comment on articles by Schiff, Emery et al, and others.
V Strand, S L Morgan, J E Baggott...
https://pubmed.ncbi.nlm.nih.gov/11083294Guidelines for folate supplementation in rheumatoid arthritis patients treated with methotrexate: comment on the guidelines for monitoring drug therapy.
G S Alarcón, S L Morgan
https://pubmed.ncbi.nlm.nih.gov/9041955