Actively Recruiting
Antisecretory Factor In Severe Traumatic Brain Injury
Led by Peter Siesjö · Updated on 2026-01-21
20
Participants Needed
1
Research Sites
381 weeks
Total Duration
On this page
Sponsors
P
Peter Siesjö
Lead Sponsor
S
Skane University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury. Half of the participants will be administered Salovum while the other half will be given a placebo egg yolk powder, not enriched for antisecretory factor. Intracranial pressure (ICP), partial brain oxygen pressure (PtbO2), microdialysis of metabolites and inflammatory mediators and trauma intensity level (TIL) will be assessed in all patients.
CONDITIONS
Official Title
Antisecretory Factor In Severe Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Severe traumatic brain injury with Glasgow Coma Scale score less than 9 at admission to the Neuro Intensive Care Unit
- Clinical need for insertion of intracranial pressure monitor, brain oxygen pressure monitor, and microdialysis catheter
- Consent obtained from relatives or guardians
You will not qualify if you...
- Known allergy to egg yolk
- Unilateral or bilateral fixed and dilated pupils after initial brain surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Skane University Hopsital
Lund, Sweden, 22185
Actively Recruiting
Research Team
P
Peter Siesjö, MD, PhD
CONTACT
D
David Cederberg, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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