Actively Recruiting

Early Phase 1
Age: 18Years - 55Years
All Genders
ID05024760

Antiseptic Effects on the Dental Implant Internal Surface Microbiome Evaluating Chlorhexidine and Hydrogen Peroxide to Reduce Implant Failure and Infection

Led by Madigan Army Medical Center · Updated on 2024-12-27

150

Participants Needed

1

Research Sites

170 weeks

Total Duration

On this page

Sponsors

M

Madigan Army Medical Center

Lead Sponsor

U

United States Department of Defense

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research focuses on soldiers who face higher risks of oral injuries that can lead to poor dental health, which impacts military readiness. The study evaluates how placing disinfectant gels inside dental implants affects implant failure, bacterial load, and the types of bacteria present. It aims to improve success rates of dental implants by reducing harmful bacteria that cause bone loss and inflammation around the implant area. The study compares two disinfectant gels, chlorhexidine and hydrogen peroxide, which are inserted into the internal cavity of dental implants during their placement. These treatments are assessed for their ability to reduce bacterial growth and improve the health of the implant site. The research builds on previous findings supporting chlorhexidine use but also investigates hydrogen peroxide's effects, which have not been studied as extensively. Participants will be monitored for implant failure four months after insertion. Researchers will measure bone loss, tissue inflammation, bacterial load, and changes in the bacterial community around the implant. The study includes ongoing assessments of implant health, inflammation, and microbiome changes to determine the disinfectants' impact on implant success and readiness. The total study participation includes the treatment period and follow-up monitoring to evaluate outcomes comprehensively.

CONDITIONS

Official Title

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Who Can Participate

Age: 18Years - 55Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Active duty military
  • Between 18 and 55 years old
  • At least 6 months remaining at local duty station
Not Eligible

You will not qualify if you...

  • Current tobacco user
  • Taking medications that affect soft tissue or bone healing
  • Having a metabolic disorder that affects soft tissue or bone healing
  • Having active periodontal disease

AI-Screening

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Trial Site Locations

Total: 1 location

1

Madigan Army Medical Center

Tacoma, Washington, United States, 98431

Actively Recruiting

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Research Team

K

Kevin D Smith, DMD

Z

Zachary T Colburn, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

3

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Published Research Related To This Trial

Retrospective analysis of dental implants among United States Air Force basic military trainees.

Shelrethia O Battle-Siatita, Joseph A Bartoloni, Raymond H Hancock...

https://pubmed.ncbi.nlm.nih.gov/19485117

Transfer of Bacteria into the Internal Cavity of Dental Implants After Application of Disinfectant or Sealant Agents In Vitro.

Anke Podhorsky, Stefanie Biscoping, Peter Rehmann...

https://pubmed.ncbi.nlm.nih.gov/27183065

Bacterial Contamination of the Internal Cavity of Dental Implants After Application of Disinfectant or Sealant Agents Under Cyclic Loading In Vitro.

Anke Podhorsky, Sven Putzier, Peter Rehmann...

https://pubmed.ncbi.nlm.nih.gov/27611755