Actively Recruiting
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
Led by University College, London · Updated on 2024-05-22
990
Participants Needed
6
Research Sites
39 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether an Artificial Intelligence (AI) based computer program can effectively automate two key parts of the radiotherapy treatment process for cancers of the cervix, head and neck, and prostate. This study focuses on whether the AI can outline anatomical areas at risk of tumour spread and radiation damage, and define the radiation beam parameters. The goal is to see if the AI can maintain quality standards while potentially improving treatment accuracy and reducing the time and human effort needed for radiotherapy. The AI program uses CT scans taken during treatment planning and uploads them to a web-based Radiotherapy Planning Assistant. This tool automatically contours target organs and high-risk disease areas and defines the size, shape, and number of radiation beams required. The final plan is then downloaded for dose recalculation and clinical peer review before use. Importantly, patients in this study are not treated with the AI-generated plan; instead, the manual plans created by local treatment teams are used. Participants in the study are patients with confirmed cervical, head and neck, or prostate cancer who have consented to radical radiotherapy. The study measures the proportion of radiotherapy plans that meet clinical acceptability before treatment, compares the time and human resources needed between AI-assisted and manual plans, and evaluates cost differences. The study is observational and tracks these outcomes without changing the patients' actual treatment plans.
CONDITIONS
Brief Title
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with confirmed head and neck cancers (oropharynx, larynx, hypopharynx, nasopharynx) Stage I-III consenting to radical radiotherapy
- Patients with confirmed primary cervical cancer Stage IB-IIIB including pelvic node positive consenting to radical radiotherapy
- Patients with confirmed primary prostate cancer T1-4N0M0 consenting to radical radiotherapy
- Mental capacity to understand and consent to participate
- Age 18 years or older
You will not qualify if you...
- Patients requiring radiotherapy following curative surgery or surgery intended to remove most of the tumour
- Patients receiving palliative radiotherapy
- Patients younger than 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Prior to first treatment
Participants undergo CT scans that are uploaded to an AI auto-planning tool for radiotherapy treatment planning evaluation. The AI-generated plans are compared with standard manual plans, but participants receive the manual plans for their treatment.
1 visit (in-person) for CT scan and planning
Duration - During radiotherapy treatment and treatment interval
Participants are observed to compare treatment planning outcomes, resource use, and costs between AI-assisted and manual radiotherapy planning methods during their radiotherapy treatment and follow-up period.
Visits as per standard radiotherapy treatment schedule
Trial Site Locations
Total: 6 locations
1
Tata Medical Centre
Kolkata, India
Actively Recruiting
2
Tata Memorial Hospital
Mumbai, India
Actively Recruiting
3
King Hussein Cancer Center
Amman, Jordan
Actively Recruiting
4
University of Malaya Medical Center
Kuala Lumpur, Malaysia
Actively Recruiting
5
Groote Schuur Hospital
Cape Town, South Africa
Actively Recruiting
6
Tygerberg Hospital
Stellenbosch, South Africa
Not Yet Recruiting
Research Team
A
ARCHERY Trial Manager
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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