Assessment of Circuit Rebreathing During Continuous Positive Airway Pressure (CPAP) Therapy in Obstructive Sleep Apnea

What this Trial Is About

Researchers are studying how different designs of continuous positive airway pressure (CPAP) masks affect airflow and the rebreathing of exhaled carbon dioxide during sleep in people with obstructive sleep apnea (OSA). This study aims to understand the severity of circuit rebreathing by measuring oxygen and carbon dioxide levels during both wakefulness and sleep. The research focuses on various CPAP settings with different pressure levels and exhaust flow rates to compare their effects. Participants will receive CPAP therapy with varying pressures of 0, 5, or 10 cmH2O and different exhaust port flow rates ranging from 8 to 35 liters per second. The study includes multiple conditions combining these pressures and flow rates to assess their impact on breathing during sleep. The primary comparison is between two specific exhaust flow rates at 5 cmH2O pressure to evaluate oxygen intake levels. During the study, participants will be monitored for changes in the average inspired oxygen fraction both while awake and asleep, along with the hypoxic burden during sleep. These measurements will help determine how CPAP mask designs influence breathing quality. The research will last approximately one year, with continuous monitoring and assessment of breathing parameters to gather detailed information about treatment effects and safety.

Assessment of Circuit Rebreathing During CPAP Therapy