Actively Recruiting

Phase Not Applicable
Age: 3Years +
All Genders
Healthy Volunteers
ID06181149

Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter

Led by Arizona State University · Updated on 2025-08-21

300

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

Sponsors

A

Arizona State University

Lead Sponsor

U

University of Washington

Collaborating Sponsor

AI-Summary

What this Trial Is About

Stuttering affects communication and the quality of life for individuals who experience it. This research aims to build a strong foundation for developing brain and behavior-based treatments for stuttering. Participants will engage in activities such as naming pictures, reading words or sentences silently or aloud, and listening to speech and nonspeech sounds while their speech, muscle, and brain signals are recorded. Some may also receive brain stimulation during reading and speaking tasks. The study involves different behavioral interventions to explore how the brain processes speech and auditory feedback in people who stutter. Four experimental groups will experience various interventions including delayed speech initiation using brain stimulation, auditory errors with brain activity monitoring during speech, electrical stimulation of a specific speech brain area, and delayed auditory feedback to create mismatches between predicted and heard speech. Participants will be involved in sessions lasting up to two hours where brain activity and speech changes are measured, especially observing how the brain responds before and during speaking and when auditory errors occur. The research monitors brain signals, speech patterns, and muscle activity during these tasks to better understand stuttering. The study is sponsored by Arizona State University and includes healthy volunteers aged 3 years and older.

CONDITIONS

Brief Title

Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter

Who Can Participate

Age: 3Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Be a monolingual, native speaker of American English
  • Have no developmental, psychological, neurological, or communication disorders other than developmental stuttering as confirmed by a certified research speech-language pathologist
  • Have normal age-appropriate binaural pure-tone hearing thresholds (0.5-4k Hz;  25 dB HL if younger than 70 years,  35 dB HL if older than 70 years)
  • Not be taking any medications that affect the central nervous system
  • Have no safety contraindications for tDCS, TMS, and MRI (for adults)
  • Score at or above the 20th percentile on standardized speech-language tests (for children)
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - Each session may last up to 2 hours

Participants undergo experimental behavioral interventions involving speech production with various auditory feedback manipulations and brain stimulation techniques while their brain activity is recorded.

1 or more sessions depending on group assignment

Trial Site Locations

Total: 2 locations

1

Arizona State University

Tempe, Arizona, United States, 85287

Actively Recruiting

2

Univeristy of Washington

Seattle, Washington, United States, 98105

Actively Recruiting

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Research Team

A

Ayoub Daliri, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

4

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