Actively Recruiting
Integrated Delivery of Cancer Control Interventions for Adolescents and Young Adults Living With HIV in Zambia
Led by Implenomics · Updated on 2026-01-15
4100
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
I
Implenomics
Lead Sponsor
P
Population Council
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adolescents and young adults living with HIV in Zambia face higher risks of developing cancers such as Kaposi sarcoma, non-Hodgkin's lymphoma, and cervical cancer compared to their uninfected peers. This research aims to evaluate peer-to-peer education and support strategies designed to increase early cancer diagnosis and improve treatment completion among this vulnerable group. The ARROW program is being tested against a one-time education campaign to determine its effectiveness in reducing premature cancer mortality in this population. The study compares two approaches: the ARROW strategies, which include peer counselors supporting patients, peer-led education sessions for providers, and a collaborative forum involving health administrators and policy makers; and a one-time education campaign providing informational brochures alongside usual care. These interventions are implemented within HIV treatment facilities and cancer centers to boost early cancer screening and ensure adherence to recommended treatments. Participants will be followed for up to three years, with key assessments including completion of cancer screenings and treatments within 12 months of enrollment or diagnosis. Researchers will monitor the proportion of patients who complete screenings, initiate and complete cancer treatment, and survive at 12 months. Implementation outcomes like acceptability and cost-effectiveness of the ARROW program will also be studied to support future scaling of these strategies in Zambia and potentially other regions.
CONDITIONS
Brief Title
AYAHIV Role-based Responsibilities for Oncology-focused Workforce (ARROW)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 15 to 39 years at time of enrollment
- Currently taking antiretroviral medication (ART) for at least 6 months
- No plans to move from current residence during the 3-year study duration
You will not qualify if you...
- Pregnant at study enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 months after study enrollment
Participants are observed to assess uptake of cancer screening services and early diagnosis interventions.
Periodic visits during the 12 months for screening and physical examination
Duration - 12 months after diagnosis
Participants diagnosed with cancer are monitored to evaluate completion of recommended cancer treatment and survival outcomes.
Follow-up visits up to 12 months post-diagnosis for treatment adherence and survival assessment
Trial Site Locations
Total: 1 location
1
Public Health Facilities
Lusaka, Zambia
Actively Recruiting
Research Team
S
Sujha Subramanian
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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