Actively Recruiting
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
Led by The First Affiliated Hospital of Dalian Medical University · Updated on 2025-04-11
100
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers. While BZDs are established treatments for conditions like anxiety and insomnia, recent warnings highlight risks, including neurocognitive effects. Neuroimaging studies indicate potential neuroprotective effects of BZDs. Functional near-infrared spectroscopy (fNIRS) measures cerebral cortex function during cognitive tasks. Combining fNIRS with mood and cognitive scales, this study assesses cortical activation. 2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) evaluates brain metabolism. DPA-714 PET assesses neuroinflammation. The primary objective is to compare brain functional activation, metabolism, and neuroinflammatory levels between long-term BZD users and non-users. This comprehensive approach aims to provide insights into BZD effects on cognition and associated brain markers.
CONDITIONS
Official Title
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Continuous use of benzodiazepines for 3 months or more, matched with participants who have not taken benzodiazepines
- At least 6 years of education
- Abstained from alcohol, coffee, and other psychoactive substances in the 24 hours before the examination
You will not qualify if you...
- Brain damage due to causes such as head trauma, dementia, epilepsy, or brain tumors
- Severe systemic diseases such as malignant tumors
- Acute cerebrovascular disease in the past 3 months
- History of substance abuse other than benzodiazepines, including alcohol and opioids
- Inability to cooperate with fNIRS, PET/MRI examinations, and scale assessments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116000
Actively Recruiting
Research Team
H
Hui min Zhang
CONTACT
M
Mei chen Liu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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