Study of Amino Acid Infusion to Prevent Acute Kidney Injury and Reduce Ventilator Use in Children After Heart Surgery

What this Trial Is About

This research aims to find out if an amino acid infusion can lower the risk of acute kidney injury in children undergoing cardiac surgery. The study focuses on children up to 18 years old who are at high risk for this kidney problem after surgery. Researchers want to know if giving amino acids can reduce how many children develop acute kidney injury and how long they need help breathing with a ventilator after surgery. Participants will receive either an amino acid infusion or a placebo infusion that looks the same but contains no active drug. The infusion is given for up to 72 hours, starting during the cardiac surgery and continuing only while the child is in the operating room or intensive care unit. The amino acid dose is 2 grams per kilogram of body weight per day, matched by volume in the placebo group. During the study, children will be monitored from enrollment through the fourth day after surgery. Researchers will check for signs of acute kidney injury on days 2, 3, and 4 after surgery and measure the use of mechanical ventilation up to 96 hours post-operation. The study includes careful tracking of safety and effects while the infusion is given and during the immediate recovery period after surgery. Participation lasts through these early post-operative days to assess outcomes.

Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy