Biomarkers and Inflammation in Solid Organ Transplantation Relationship With Short- and Long-Term Outcomes

What this Trial Is About

This research focuses on adult patients who have undergone solid organ transplantation, including heart, liver, lung, or kidney transplants. The study aims to measure biological markers related to inflammation, cellular aging, and immune system aging. These measurements could help identify patients at higher risk of transplant failure or other serious complications like cardiovascular, kidney, metabolic, or cancer-related issues, as well as increased mortality. The study also seeks to develop personalized treatments based on these biological markers to prevent further damage. The study will collect various biological samples to analyze plasma profiles of cytokines, inflammatory microRNAs, circulating free DNA, and extracellular vesicles. It will also study immune cell aging and epigenetic aging patterns in tissues and blood. These data will be used to better understand patient risks and to tailor immunosuppressive therapies more effectively. The study is conducted within specialized units for heart, liver, lung, and kidney transplantation at the IRCCS Azienda Ospedaliero-Universitaria di Bologna. Participants will be adults who have received at least one of the specified organ transplants. Researchers will monitor adverse events related to heart, liver, lung, and kidney transplants over a seven-year period. The study involves long-term follow-up to assess outcomes and gather data on biological aging and inflammation. This monitoring will help evaluate how these markers relate to transplant success and patient health over time.

Biomarkers and Inflammation in Solid Organ Transplantation: Relationship With Short- and Long-Term Outcomes