Long-term Health Study of Children Born to Mothers After Solid Organ Transplants Including Kidney, Liver, Pancreas, Heart, and Lung Transplants

What this Trial Is About

Researchers are investigating the long-term health of children born to mothers who have undergone solid organ transplantation, such as kidney, liver, pancreas, heart, or lung transplants. These pregnancies may carry higher risks like preeclampsia and preterm birth, and the effects of immunosuppressive medication on the childs development are not well understood. This observational study aims to assess cardiovascular and kidney health, immune status, and overall development of these offspring, comparing them with general population data and across different transplant types. The study involves a one-time visit where participants will complete questionnaires and undergo physical tests including kidney ultrasound, body measurements, and blood pressure monitoring. Biological samples such as urine, blood, and feces will be collected for health assessment and biobanking, with blood samples being optional. For children under 16 years, less invasive tests like blood pressure via a dynamap device will be performed, and no biological samples or kidney ultrasounds will be taken. The study will also gather medical history from healthcare records and compare data with control groups from existing cohorts. Participants will provide information about their growth, development, medication use, and health conditions through questionnaires and medical records review. Researchers will measure outcomes like blood pressure, kidney function, metabolic markers, and immune parameters. Quality of life and educational attainment will also be assessed. This cross-sectional study expects to include about 150 to 220 participants and collects data to better understand health risks and guide future counseling and interventions for families after transplantation pregnancies.

Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation