Study of Digital Biomarkers and Protein Patterns to Understand Recovery in Children and Young Adults Undergoing Surgery for Solid Tumors

What this Trial Is About

Researchers are studying how children and their families recover after major cancer surgery. This observational study aims to understand recovery patterns and resilience by using data from patients and caregivers. The study also looks at specific protein and metabolite patterns linked to surgery-related stress. It focuses on children and young adults with extracranial solid tumors undergoing surgery. Participants will wear smartwatches to collect activity, heart rate, and sleep data starting before surgery and continuing for one year after. They will complete questionnaires about their quality of life and mood at multiple timepoints before and after surgery. Extra blood samples may be taken during routine clinical blood draws for research analysis. Clinical data such as diagnosis, treatment, and surgery outcomes will also be collected. Participants and their caregivers will be asked to wear the smartwatch continuously except during certain activities. Questionnaires can be done electronically, by phone, or in person at scheduled intervals up to one year post-surgery. Researchers will evaluate surgical resilience over one year using wearable data, questionnaires, blood biomarkers, and clinical information. There are no changes to clinical care, and participants will receive compensation for their time.

Biomarkers of Resiliency In Childhood Cancer Surgery