Pilot Study Evaluating Safety and Brain Effects of 40Hz Light, Sound, and Tactile Stimulation Devices in Healthy Adults

What this Trial Is About

Researchers are studying the effects of non-invasive 40Hz sensory stimulation using light, sound, and tactile devices on brain activity in cognitively normal, healthy adults. This pilot study aims to explore whether such stimulation can alter brain oscillations and connectivity, improve neuropsychological measures, and affect blood biomarkers and the microbiome. The study is motivated by findings that disruptions in gamma-band brain activity are linked to Alzheimers disease and cognitive impairment, and current treatments have limited effectiveness. Participants receive stimulation from devices delivering light and sound at a 40Hz frequency, including a light and sound device with LEDs and speakers and a wrist- or hand-worn device that provides tactile vibrations. The devices are used during a one-day visit at MIT, where participants experience the stimulation in a controlled setting while watching videos for entertainment. During the visit, investigators evaluate the effects and safety of the GENUS stimulation using EEG, MEG, MRI scans, neuropsychological testing, and blood sampling in some participants. The primary outcome is to measure changes in brain oscillations after one year. This study involves adults aged 18 to 100 years, and participants are monitored for any biological effects and safety signals throughout the process.

Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)