Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.
M L Woodward, K M Gicas, D E Warburton...
https://pubmed.ncbi.nlm.nih.gov/30539767Actively Recruiting
Age: 19Years - 45Years
All Genders
Healthy Volunteers
ID01392885
Brain Health: Effects of Exercise on Hippocampal Volume and Memory Deficits in Persons With Schizophrenia
Led by BC Mental Health and Addictions Research Institute · Updated on 2023-06-08
60
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
B
BC Mental Health and Addictions Research Institute
Lead Sponsor
U
University of British Columbia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how aerobic exercise affects brain structure and psychotic symptoms in individuals with schizophrenia or schizoaffective disorder compared to healthy volunteers of similar age and gender. The study aims to see if aerobic exercise can increase hippocampal volume and improve memory and cognitive function, while also assessing stroke risk using a new retinal imaging technique. This research addresses cognitive challenges and early stroke risk that are not well managed by current treatments for psychosis. This 12-week randomized trial includes two exercise groups: aerobic and resistance training. Participants, including both patients and healthy volunteers, will follow their assigned exercise program while continuing any prescribed medications. Exercise sessions and fitness assessments will be supervised by trained professionals, with intensity adjusted to each participant's needs. Training will take place at hospital and university exercise facilities. Participants will undergo clinical evaluations, including medication review, symptom assessment, heart rate, blood pressure, and weight measurements. Brain and retinal imaging will be done at the start and end of the study. Cognitive tests focusing on executive function and memory will be administered at baseline and follow-up for those who continue participating. The main outcome measured is the change in hippocampal volume after aerobic exercise, along with improvements in memory performance and stroke risk indicators.
CONDITIONS
Brief Title
Brain Health and Exercise in Schizophrenia
Who Can Participate
Age: 19Years - 45Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 18 to 45 years
- Able to provide written, informed consent in English
- Patients may be on prescribed medications
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Normal visual acuity (or normal visual acuity achievable with corrective lenses)
- Physical ability to be engaged in a regular exercise program
You will not qualify if you...
- History of organic disorders (dementia, severe head injury, autism, mental retardation, Down's Syndrome)
- Current DSM-IV diagnosis of substance dependence (past 12 months, excluding tobacco)
- History of other DSM-IV Axis I psychiatric disorders
- History of angina, heart attack, or transient ischemic attacks
- Non-independent mobility or limb prostheses
- History of severe head injury with loss of consciousness > 5 minutes
- Contraindications for neuroimaging (metal implants, non-removable orthodontic devices, severe claustrophobia, pregnancy, recent surgeries)
- Currently enrolled in a regular exercise program
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - 12 weeks
Participants undergo assessments including neuroimaging, retinal imaging, and cognitive testing at baseline and follow-up to measure brain health and memory performance.
Assessments at baseline, Week 4, Week 8, and Week 12
Trial Site Locations
Total: 1 location
1
UBC Hospital
Vancouver, British Columbia, Canada, V6T 1Z3
Actively Recruiting
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Research Team
D
Donna J Lang, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Heart-rate response to alpha2-adrenergic receptor antagonism by antipsychotics.
David D Kim, Donna J Lang, Darren E R Warburton...
https://pubmed.ncbi.nlm.nih.gov/28674870