Effects of Aerobic Exercise on Brain Volume and Memory in Adults with Schizophrenia or Schizoaffective Disorder

What this Trial Is About

Researchers are investigating how aerobic exercise affects brain structure and psychotic symptoms in individuals with schizophrenia or schizoaffective disorder compared to healthy volunteers of similar age and gender. The study aims to see if aerobic exercise can increase hippocampal volume and improve memory and cognitive function, while also assessing stroke risk using a new retinal imaging technique. This research addresses cognitive challenges and early stroke risk that are not well managed by current treatments for psychosis. This 12-week randomized trial includes two exercise groups aerobic and resistance training. Participants, including both patients and healthy volunteers, will follow their assigned exercise program while continuing any prescribed medications. Exercise sessions and fitness assessments will be supervised by trained professionals, with intensity adjusted to each participants needs. Training will take place at hospital and university exercise facilities. Participants will undergo clinical evaluations, including medication review, symptom assessment, heart rate, blood pressure, and weight measurements. Brain and retinal imaging will be done at the start and end of the study. Cognitive tests focusing on executive function and memory will be administered at baseline and follow-up for those who continue participating. The main outcome measured is the change in hippocampal volume after aerobic exercise, along with improvements in memory performance and stroke risk indicators.

Brain Health and Exercise in Schizophrenia