Study of Spinal Cord Stimulation to Activate Brown Fat for Weight Loss and Type 2 Diabetes Treatment in Adults with Back Pain

What this Trial Is About

Researchers are investigating whether spinal cord stimulation SCS can activate brown adipose tissue BAT metabolism to support weight loss and potentially ease Type 2 diabetes. This study focuses on adults aged 21 to 70 years with persistent neuropathic leg and back pain who are planning to undergo SCS for pain control. The research aims to provide proof-of-concept evidence for a new treatment approach targeting morbid obesity and diabetes. Participants will have a second research electrode placed in the epidural space near the upper thoracic spine during their SCS trial implant procedure. Each participant will undergo two PETCT scans on days 3 and 5 after electrode implantation one scan at baseline without SCS activation and one with SCS activated, in randomized order. The scans will assess BAT metabolism using a special marker and imaging technique. During the study, participants will be monitored through these PETCT scans to measure BAT activation levels. Researchers will evaluate the maximum standardized uptake value SUVmax and compare BAT activity on both sides of the body during SCS activation. The study includes safety monitoring and ends approximately one week after electrode implantation. Data collected will help understand how SCS influences metabolism related to weight loss and diabetes.

Brown Adipose Tissue Activation by Spinal Cord Stimulation