Actively Recruiting
Fostering Patient-oriented Research in Cardiometabolic Disease Pathogenesis and Prevention
Led by University of Washington · Updated on 2025-06-06
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Washington
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how nutritious foods affect inflammation in the hypothalamus of children who are overweight or have obesity. The study aims to use magnetic resonance imaging (MRI) to evaluate this effect and to assess how feasible and acceptable feeding intervention strategies are for these children. The research focuses on children aged 9 to 11 years and explores diet's role in cardiometabolic disease prevention. The study includes three parts: In one, adult caregivers join focus groups to discuss feeding study participation while children complete a taste test of proposed menus. In the second, children receive all meals with nutritious foods for a 7-day period, followed by 7 days of their usual diet. The third part involves another focus group with caregivers to learn about family experiences with feeding research. No other medical treatments are involved. Participants will attend focus groups and taste tests, and children will have MRI scans to measure brain inflammation using T2 relaxation time after the diet intervention. Researchers will monitor meal consumption and diet adherence during the 7-day provided meal period. The total participation duration varies by study part, with assessments designed to evaluate the intervention's impact and family perspectives on study participation.
CONDITIONS
Brief Title
Building Research for Intervention Development in Gliosis and Eating Habits
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child age 9 to 11 years
- For Study 1: Adult caregiver and child willing to attend an in-person focus group
- For Study 2: Child with BMI at or above the 85th percentile and below the 95th percentile for age and sex
- For Study 3: Adult caregiver with child qualifying for free or reduced-cost lunch in Washington State and child with overweight
You will not qualify if you...
- Significant health conditions including type 2 diabetes
- History of major weight loss or eating disorder
- Current use of medications known to alter appetite or body weight (e.g., stimulants for ADHD)
- Documented cognitive disorder
- Severe food allergies, vegetarian, or vegan diet (Study 1 and Study 2)
- Unable to attend session date (Study 1)
- MRI contraindications such as braces or claustrophobia (Study 2)
- Weight over 330 pounds (MRI limit) (Study 2)
- Currently in a formal weight loss program (Study 2)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 14 days
Participants in Study 2 will be provided all meals for a 7-day period, consuming meals ad libitum. For the other 7 days, participants will consume their usual diet.
1 baseline visit and 1 follow-up visit
Trial Site Locations
Total: 1 location
1
University of Washington
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
B
BRIDGE Study
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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