Actively Recruiting

Age: 18Years +
All Genders
ID06414551

Characteristics of Calcification in a Chronic Total Occlusion on Computed Tomography Coronary Angiogram and Percutaneous Coronary Intervention Outcomes - a Single Centre Observational Study

Led by Sandwell & West Birmingham Hospitals NHS Trust · Updated on 2024-08-30

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating the relationship between calcification characteristics seen on Computed Tomography Coronary Angiography (CTCA) and the outcomes of Percutaneous Coronary Intervention (PCI) in patients with chronic total occlusion (CTO) of the coronary artery. This observational study focuses on patients who underwent CTO PCI attempts and had CTCA scans at the study center within the last five years. The study aims to understand how calcification affects the success of PCI procedures and the use of calcium modification tools. The study involves reviewing medical records and imaging of patients who had both CTO PCI attempts and CTCA. Characteristics of calcification such as location, density measured in Hounsfield units, and quantity in the CTO will be analyzed and correlated with PCI success or failure. The study will also assess how calcium modification tools were used during PCI and their relationship to the severity of calcification. Statistical analyses will compare demographic and procedural data with calcification features and PCI outcomes. Participants will have their CTCA images and PCI reports reviewed retrospectively after providing consent through mailed forms. Researchers will analyze baseline patient data, calcification details, and procedural results. The main outcome measure is the correlation between calcification characteristics and PCI success or failure within 24 hours. Secondary measures include evaluating the role of calcium modifying tools relative to calcification severity. Participation involves no new treatment or intervention and is based on existing clinical data collected over the past five years.

CONDITIONS

Brief Title

Calcification on CTCA of a CTO and PCI Outcomes

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Previous CTO PCI attempt within the last 5 years
  • Undergone CTCA either before or after CTO PCI
  • CTCA images are of adequate quality for analysis
Not Eligible

You will not qualify if you...

  • Under 18 years of age
  • Did not undergo CTCA
  • CTCA images are inadequate or degraded

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

No in-person visits; consent and information are exchanged by mail and telephone.

Diagnostic Evaluation

Duration - Up to 24 hours

Participants' CTCA images and PCI procedure data are reviewed and analyzed for characteristics of calcification and procedural outcomes.

No additional visits; data review is conducted remotely.

Trial Site Locations

Total: 1 location

1

Birmingham City Hospital, Sandwell and West Birmingham NHS Trust

Birmingham, West Midlands, United Kingdom, B18 7QH

Actively Recruiting

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Research Team

V

Vinoda Sharma, FRCP

K

Kelly Hard

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Angiographic success and procedural complications in patients undergoing percutaneous coronary chronic total occlusion interventions: a weighted meta-analysis of 18,061 patients from 65 studies.

Vishal G Patel, Kimberly M Brayton, Aracely Tamayo...

https://pubmed.ncbi.nlm.nih.gov/23352817

Establishing the cost-effectiveness of percutaneous coronary intervention for chronic total occlusion in stable angina: a decision-analytic model.

Hemal Gada, Patrick L Whitlow, Thomas H Marwick

https://pubmed.ncbi.nlm.nih.gov/23038791

Quantifying the early health status benefits of successful chronic total occlusion recanalization: Results from the FlowCardia's Approach to Chronic Total Occlusion Recanalization (FACTOR) Trial.

J Aaron Grantham, Philip G Jones, Louis Cannon...

https://pubmed.ncbi.nlm.nih.gov/20388873

Immediate results and one-year clinical outcome after percutaneous coronary interventions in chronic total occlusions: data from a multicenter, prospective, observational study (TOAST-GISE).

Zoran Olivari, Paolo Rubartelli, Federico Piscione...

https://pubmed.ncbi.nlm.nih.gov/12767645

A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions.

Gerald S Werner, Victoria Martin-Yuste, David Hildick-Smith...

https://pubmed.ncbi.nlm.nih.gov/29722796

Contemporary issues of percutaneous coronary intervention in heavily calcified chronic total occlusions: an expert review from the European CTO Club.

Kambis A Mashayekhi, Stylianos A Pyxaras, Gerald S Werner...

https://pubmed.ncbi.nlm.nih.gov/36971414

Predicting successful guidewire crossing through chronic total occlusion of native coronary lesions within 30 minutes: the J-CTO (Multicenter CTO Registry in Japan) score as a difficulty grading and time assessment tool.

Yoshihiro Morino, Mitsuru Abe, Takeshi Morimoto...

https://pubmed.ncbi.nlm.nih.gov/21349461

Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score.

Georgios Christopoulos, David E Kandzari, Robert W Yeh...

https://pubmed.ncbi.nlm.nih.gov/26762904