Actively Recruiting
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
Led by University of Minnesota · Updated on 2025-07-16
125
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how regular use of cannabidiol (CBD) affects the body's psychobiological responses to stress. This study compares adults who use CBD regularly with those who do not, aiming to understand differences in how they respond to acute stress. The study also collects information about related factors like tobacco use. Participants will undergo a behavioral stress intervention that includes preparing and delivering a speech, performing mental arithmetic in front of evaluators, and completing a cold pressor task by submerging their hand in ice water. The study includes adults aged 21 to 70 who either use CBD regularly or do not use it. There are no placebo or comparison drugs used; the focus is on observing stress responses in these two groups. During the study visit, researchers will measure changes in subjective feelings such as stress, anxiety, and positive mood, as well as monitor cardiovascular activity and cortisol levels over approximately 2.5 hours. Participants will also provide information about their lifestyle and behaviors, including tobacco use. The study aims to gather detailed data on how CBD use may relate to the body's reaction to acute stress, with all procedures occurring during the study visit.
CONDITIONS
Brief Title
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults who are relatively healthy and aged 21-70 years.
- Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
- Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
You will not qualify if you...
- Participated in previous acute stress studies that included a similar stress induction.
- Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
- Self-reported current pregnancy.
- Self-reported current use of illicit substances (other than cannabis).
- Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
- Students of the principal researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2.5 hours
Participants undergo a behavioral stress induction including speech preparation and delivery, mental arithmetic, and a cold pressor task to study psychobiological stress responses.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
S
Stress and Resilience Research Labs
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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