Actively Recruiting
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
Led by Icahn School of Medicine at Mount Sinai · Updated on 2024-08-09
500
Participants Needed
4
Research Sites
386 weeks
Total Duration
On this page
Sponsors
I
Icahn School of Medicine at Mount Sinai
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study team will determine the association between d,l-methylphenidate (MPH) therapeutic outcomes in ADHD patients and genetic variants of CES1 and reveal key associations between CES1 genotypes and the PK and PD of MPH.
CONDITIONS
Official Title
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Youth ages 6-17 years with ADHD as a primary diagnosis
You will not qualify if you...
- Participants that do not have ADHD as a primary diagnosis
- Participants that do not want, require, or are not healthy enough for a single dose trial of MPH for ADHD per the clinical judgment of the treating and study clinicians
- Participants that are smokers or, are pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
2
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
3
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Completed
4
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Terminated
Research Team
B
Beth Krone, PhD
CONTACT
J
John Markowitz, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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