Actively Recruiting
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
Led by University of Southern California · Updated on 2026-05-13
240
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
U
University of California, Irvine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
CONDITIONS
Official Title
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fluent in English
- Black/African-American or White/European-American
- Aged between 50-70 years old
- Non-pregnant and non-menstruating for at least the past year
- Have normal or corrected-to-normal vision and hearing
- Have reliable access to wifi
- Have an email account that you check regularly
- Have a phone that receives text messages
- Agree to provide blood and urine samples at two campus visits
- Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits
You will not qualify if you...
- Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
- Have cognitive impairment
- Have regularly played Lumosity games in the past 6 months
- Have any conditions not safe for MRI including:
- Metal in any parts of your body
- Claustrophobia
- Worked as a machinist, metal worker, or in any profession or hobby grinding metal
- Injury to the eye involving a metallic object
- Cardiac pacemaker
- Implanted cardiac defibrillator
- Aneurysm clip or brain clip
- Carotid artery vascular clamp
- Neurostimulator
- Insulin or infusion pump
- Spinal fusion stimulator
- Cochlear, otologic, ear tubes or ear implant
- Prosthesis (eye/orbital, penile, etc.)
- Implant held in place by a magnet
- Heart valve prosthesis
- Artificial limb or joint
- Other implants in body or head
- Electrodes (on body, head or brain)
- Intravascular stents, filters
- Shunt (spinal or intraventricular)
- Vascular access port or catheters
- IUD
- Transdermal delivery system or other types of foil patches that cannot be removed for MRI
- Shrapnel, buckshot, or bullets
- Tattooed eyeliner or eyebrows
- Body piercing(s) that cannot be removed for MRI
- Metal fragments (eye, head, ear, skin)
- Internal pacing wires
- Aortic clips
- Metal or wire mesh implants
- Wire sutures or surgical staples
- Harrington rods (spine)
- Bone/joint pin, screw, nail, wire, plate
- Wig or toupee that cannot be removed for MRI
- Hair implants that involve staples or metal
- Hearing aid(s) that cannot be removed for MRI
- Dentures or retainers that cannot be removed for MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Southern California
Los Angeles, California, United States, 90089
Actively Recruiting
Research Team
E
Emotion & Cognition Lab Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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