A survey of aortic disease biorepository participants' preferences for return of research genetic results.
Jamie Love-Nichols, Wendy R Uhlmann, Patricia Arscott...
https://pubmed.ncbi.nlm.nih.gov/33319384Actively Recruiting
All Genders
Healthy Volunteers
ID02306200
Cardiovascular Health Improvement Project: Observational Study Collecting Biological Samples and Clinical Data from Patients with Aortic and Cardiovascular Diseases and Healthy Controls
Led by University of Michigan · Updated on 2026-04-29
15000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to create a biobank containing clinical information, DNA, plasma, and aortic tissue samples from individuals with cardiovascular disease and healthy controls. The study focuses on patients with conditions such as aortic aneurysm, aortic dissection, bicuspid aortic valve, heart failure, and other cardiovascular diseases. It seeks to gather biological specimens and family history to support research into aortic and vascular diseases. Participants include those diagnosed with any form of aortic disease and healthy individuals without such diagnoses. The study collects blood, plasma, serum, and aortic tissue samples, building a comprehensive database linked to demographic and clinical data. This observational project does not involve specific treatments but supports research by providing high-quality, well-annotated samples. During the study, participants provide biological samples and clinical information, which researchers use to establish and maintain the biobank and database. The main outcome is the establishment of a biobank of patients with aortic disease over 40 years. The project started in 2013 and will continue through 2053, involving ongoing data and sample collection. Participants' health and consent are monitored throughout, with no intervention or treatment assigned.
CONDITIONS
Brief Title
Cardiovascular Health Improvement Project
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Any patient over the age of 18 who is able and willing to give informed consent
- Patients under 18 years of age with parental consent and assent if applicable
- Diagnosis of aortic pathology potentially due to a known or suspected inherited condition
- Diagnosis of idiopathic aortic aneurysm
- Interest in novel vascular pathology in the aorta or main branches
- Family history of aortic or vascular disease
- Other cardiovascular disease
- Healthy controls with no apparent cardiovascular disease
You will not qualify if you...
- Not willing or able to sign the consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Sample Collection
Duration - Ongoing over the study period
Participants provide biological specimens such as blood, plasma, serum, and aortic tissue and share family history information for research purposes.
Long-term Monitoring
Duration - Up to 30 years
Participants are observed over time to establish and update the biobank and comprehensive database with clinical and demographic information.
Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
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Research Team
L
Lauren Humphrey-Stark, BS
J
Jen McNamara, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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