Actively Recruiting
Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood
Led by University of Oxford · Updated on 2023-01-12
200
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
Sponsors
U
University of Oxford
Lead Sponsor
U
University of Bristol
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand why young adults born from pregnancies complicated by high blood pressure may have a higher risk of developing hypertension and heart and blood vessel diseases later in life. The study focuses on individuals in their 20s and 30s who were born to mothers with hypertensive pregnancies, seeking to identify early changes in their heart, blood vessels, and brain that could signal future disease progression. Participants attend a single four-hour visit at the University of Oxford, where detailed imaging tests including MRI scans will examine their brain, heart, liver, kidneys, and blood vessels. The study integrates these new findings with extensive existing data from previous follow-ups of the same individuals within the ALSPAC cohort to provide a comprehensive picture of cardiovascular health. During the visit, researchers will perform various assessments such as measuring heart function and structure, blood vessel properties, metabolic markers, physical activity, and brain volumes. They will also collect blood samples and use questionnaires to gather information on lifestyle factors like smoking and alcohol use. The main outcome measured is the right ventricular mass of the heart in participants aged 30 to 40. The study results will help understand disease development and inform future prevention strategies. Participation involves one study visit with no ongoing treatment or follow-up required.
CONDITIONS
Brief Title
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is willing and able to give informed consent for participation in the study
- Male or female, aged 30 to 40 years at time of enrolment
- Participant previously took part in the ALSPAC study
- Able and willing to comply with all study requirements
- Adequate understanding of verbal and written English
You will not qualify if you...
- Pregnant or lactating when due to attend study visit
- Less than six months postpartum
- Planning to donate blood within two weeks prior to study visit
- Any significant disease or disorder that may affect ability to participate
- Evidence of congenital heart disease or significant chronic cardiovascular or metabolic disease
- Unsuitable for MRI for the MRI component only; may still participate in other parts of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day or split over 2 days
Participants attend a study visit where brain, heart, liver, kidneys, and vasculature are assessed using MRI and other imaging modalities. Data from previous follow-ups and detailed pregnancy history are integrated to understand cardiovascular and related changes.
1 study visit (in-person)
Duration - Up to 7 years
Participants are observed over time to understand the progression and development of heart and blood vessel changes related to hypertensive pregnancy exposure in young adulthood.
No additional visits required as part of this study
Trial Site Locations
Total: 1 location
1
University of Oxford
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Actively Recruiting
Research Team
K
Katie Suriano
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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