A Study of the Cap-Assisted Resection Margin Assessment CARMA Technique to Improve Polyp Removal and Reduce Recurrence in Patients with Colonic Polyps

What this Trial Is About

Researchers are studying a new technique called the Cap Assisted Resection Margin Assessment CARMA to help reduce the recurrence of colonic polyps after they are removed by colonoscopy. Polyps can lead to colorectal cancer if not completely removed, and current methods sometimes miss incomplete resections. The CARMA technique aims to provide a standard way to carefully check the edges of the removed area using advanced endoscopy tools like narrow band imaging and magnification. Participants in this study will first have their polyps removed using standard polypectomy methods. Then, the CARMA technique will be applied to examine the entire margin of the polypectomy site using a cap-assisted magnification endoscope. This assessment may include narrow band imaging at the doctors discretion. This approach is being studied during the initial procedure to detect any leftover polyp tissue and ensure a clear margin. During the study, researchers will monitor how often the CARMA technique achieves a clear resection margin and its accuracy in detecting residual polyps. They will also track the rate of incomplete resections and the time needed to apply the CARMA method for different polyp sizes. Follow-up will occur according to national guidelines, between 6 months and 5 years after the procedure, to check for polyp recurrence. Participants will be closely assessed through these procedures to help evaluate the techniques potential benefits and safety.

The CARMA Technique Study