Actively Recruiting

Phase Not Applicable
Age: 20Years +
All Genders
ID05536609

Cast or Epineural Suture for Digital Nerve Injuries: A Randomised Controlled Study

Led by Karolinska Institutet · Updated on 2025-12-12

166

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Digital nerve injuries in the fingers are common and affect people of various ages. This research aims to evaluate and compare how well sensory function recovers after treatment for isolated digital nerve injuries in fingers 2 through 5, excluding the thumb. The study addresses the current lack of knowledge regarding optimal treatment approaches and sensory restoration after this type of injury. Participants will be randomly assigned to one of two treatments: surgical repair using epineural sutures or non-operative care involving immobilization of the injured finger in a plaster cast. The surgical group will have the injured nerve exposed and sutured with two or three fine synthetic sutures, followed by three weeks in a plaster cast and rehabilitation. The non-operative group will have the skin closed without exposing the nerve and the finger protected in a plaster cast for three weeks, also followed by rehabilitation. Participants will be followed up at 3 weeks, 3 months, 6 months, and 1 year after treatment to assess nerve function, finger mobility, dexterity, hand function, pain, anxiety, and time spent on sick leave. The primary outcome is measured by static two-point discrimination one year after injury. Secondary outcomes include grip strength, sensory tests, functional hand tests, pain and psychological assessments, and recording of sick leave duration. This study is sponsored by Karolinska Institutet and aims to provide comprehensive data on treatment outcomes for digital nerve injuries.

CONDITIONS

Brief Title

Cast Or ePineural Suture for Digital Nerve Injuries - a Randomised Controlled Study

Who Can Participate

Age: 20Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical signs of isolated traumatic digital nerve injury in fingers 2, 3, 4, or 5
  • Age 20 years or older on the day of injury
  • Injury located on the palm (volar) side of the finger
  • Acute sensory loss in the area of the suspected digital nerve injury
Not Eligible

You will not qualify if you...

  • Digital nerve injury to the thumb
  • Injury in the palm of the hand (proximal to finger base)
  • Inability to speak or read Swedish
  • Abusive drug or alcohol use
  • Dementia
  • Injury more than 7 days old or inability to have surgery within 10 days from injury
  • Neurologic disease
  • Infection in the injured finger
  • Tendon injury or fracture in the injured or adjacent finger
  • Injury caused by blunt force or crush mechanism

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - Up to 10 days from injury

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - 3 weeks of treatment followed by rehabilitation

Participants receive either surgical exposure and epineural suture or non-operative treatment with the injured finger protected in a plaster cast for 3 weeks, followed by rehabilitation.

1 day of surgery (for surgical arm) and 3 weeks in a plaster cast

Follow-up

Duration - Up to 1 year after inclusion

Participants attend clinical follow-up visits to assess recovery and outcomes after treatment.

Visits at 3 weeks, 3 months, 6 months, and 1 year

Trial Site Locations

Total: 1 location

1

Karolinska Institutet Södersjukhuset, Department of clinical research and education

Stockholm, Stockholm County, Sweden, 11883

Actively Recruiting

Loading map...

Research Team

C

Carin Carlsson, MD

C

Cecilia Mellstrand Navarro, MD, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Similar Trials

Function And Speed of Transection Recovery After Therapeutic...

Digital Nerve Injury

Actively Recruiting

5 locations

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here