Actively Recruiting
Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Led by Chung Shan Medical University · Updated on 2024-02-07
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Chung Shan Medical University
Lead Sponsor
N
National Science and Technology Council
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the effects of coenzyme Q10 supplementation on people with mild cognitive impairment (MCI) and Alzheimer's disease (AD) who also have high blood sugar (hyperglycemia) and either no muscle loss or early muscle loss (pre-sarcopenia). This study aims to understand how coenzyme Q10 affects blood sugar, brain health markers like brain-derived neurotrophic factor (BDNF), muscle-related proteins, and cognitive function. Alzheimer's disease is linked to brain changes similar to diabetes, and coenzyme Q10 is an antioxidant that may influence energy production and blood sugar regulation. The study is designed as a randomized, double-blind, placebo-controlled trial where participants receive either 300 mg of coenzyme Q10 daily (150 mg twice a day) or a placebo for 12 weeks. After the initial period, participants will switch treatments to compare effects. Researchers collect data on mental function, nutrition, muscle strength, quality of life, and mood. Blood samples are taken before and after treatment to measure coenzyme Q10 levels, BDNF, oxidative stress, antioxidant capacity, and other muscle and metabolic markers. Participants will be evaluated using cognitive tests, muscle strength measurements, physical performance assessments, dietary records, and questionnaires on quality of life and depression. The primary outcomes include fasting glucose, HbA1C, insulin, C-peptide, BDNF, and muscle-related proteins after 12 weeks. Secondary outcomes include oxidative stress markers, antioxidant capacity, cognitive scores, muscle mass, grip strength, and physical performance. The study will last through the treatment and follow-up periods to monitor changes and understand how coenzyme Q10 may affect metabolism and cognition in this group.
CONDITIONS
Brief Title
Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of mild cognitive impairment (MCI)
- Clinical diagnosis of Alzheimer's Disease
- MCI and AD patients with hyperglycemia (fasting glucose >=100 mg/dL)
- MCI and AD patients with pre-sarcopenia (low calf circumference, low hand grip, or low muscle endurance)
- Must be able to swallow tablets
You will not qualify if you...
- Cancer patients
- Severe heart, lung, liver, and kidney diseases
- Severe disability or aphasia
- Malnutrition (body weight changes > 5% within one month)
- Using coenzyme Q10 supplements
- Warfarin therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Duration - 12 weeks per treatment period
Participants receive coenzyme Q10 supplementation or placebo to study its effects on glucose metabolism, muscle function, and cognitive status.
Visits occur at baseline and after 12 weeks for each treatment period
Trial Site Locations
Total: 1 location
1
Chung Shan Medical University Hospital
Taichung, Taiwan
Actively Recruiting
Research Team
P
Ping-Ting Lin, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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