Actively Recruiting

Phase Not Applicable
Age: 50Years - 80Years
All Genders
NCT06040905

Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor

Led by Chung Shan Medical University · Updated on 2024-02-07

100

Participants Needed

1

Research Sites

135 weeks

Total Duration

On this page

Sponsors

C

Chung Shan Medical University

Lead Sponsor

N

National Science and Technology Council

Collaborating Sponsor

AI-Summary

What this Trial Is About

The aim of the study is to investigate the effect of coenzyme Q10 supplementation (150 mg/b.i.d, 300 mg/d, 12 weeks) on coenzyme Q10, glucose parameters, BDNF, myokines, and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients who combined with hyperglycemia but without sarcopenia, or with hyperglycemia and pre-sarcopenia.

CONDITIONS

Official Title

Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor

Who Can Participate

Age: 50Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical diagnosis of mild cognitive impairment (MCI).
  • Clinical diagnosis of Alzheimer's Disease.
  • MCI and AD patients with hyperglycemia ( Fasting glucose >=100 mg/dL).
  • MCI and AD patients with pre-sarcopenia (low calf circumference, low hand grip, or low muscle endurance).
  • Must be able to swallow tablets.
Not Eligible

You will not qualify if you...

  • Cancer patients.
  • Severe heart, lung, liver, and kidney diseases.
  • Severe disability or aphasia.
  • Malnutrition (body weight changes > 5% within one month).
  • Using coenzyme Q10 supplements.
  • Warfarin therapy.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Chung Shan Medical University Hospital

Taichung, Taiwan

Actively Recruiting

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Research Team

P

Ping-Ting Lin, Ph.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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