Exploring Combined Theta Burst Stimulation and Aerobic Exercise to Improve Thinking and Movement in Older Adults with Cognitive Frailty

What this Trial Is About

Researchers are investigating how a combination of brain stimulation and aerobic exercise can improve thinking skills, mobility, and brain function in older adults with cognitive frailty. This trial compares different types of theta burst stimulation, including intermittent theta burst stimulation iTBS primed with continuous theta burst stimulation cTBS, non-priming iTBS, and sham stimulation, to understand their effects on brain structure and function. The study aims to identify how these treatments impact cognition and movement and the brain mechanisms behind these changes. Participants will be randomly assigned to one of three groups receiving different theta burst stimulation protocols three times a week for three months cTBS followed by iTBS, sham cTBS followed by iTBS, or sham cTBS followed by sham iTBS. After each stimulation session, all participants will take part in 60-minute aerobic exercise sessions for a total of six months. The brain stimulation will be delivered using a special coil guided by MRI scans to target specific brain areas. During the study, participants will undergo tests at the start, three months, and six months to assess their cognitive abilities, mobility, and brain activity. These include memory and attention tests, physical performance measures like gait speed and balance, and brain imaging scans. Researchers will also monitor physical activity levels, mood, fatigue, and daily functioning. The total involvement includes 39 stimulation sessions and ongoing exercise, with comprehensive evaluations throughout the study period.

A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults