Actively Recruiting
A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
Led by The Hong Kong Polytechnic University · Updated on 2026-03-27
45
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are: 1. Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation? 2. What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
CONDITIONS
Official Title
A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 60 and 90 years old
- Score less than 9 out of 12 on the Short Physical Performance Battery (SPPB)
- Score more than 18 out of 30 on the Montreal Cognitive Assessment (MoCA)
- Score more than 9 out of 42 on the Pictorial Fit-Frail Scale (PFFS)
- Live in the community
- Be able to walk up to four meters with or without assistive devices
- Be able to provide written informed consent
- Understand verbal and written Cantonese and/or English
You will not qualify if you...
- Have contraindications for magnetic resonance imaging (MRI)
- Have contraindications for aerobic exercise
- Have contraindications for transcranial magnetic stimulation
- Diagnosed with neurodegenerative diseases such as dementia, Parkinson's, Alzheimer's disease, amyotrophic lateral sclerosis, or stroke
- Live in a nursing home or other care facility
- Take fixed doses of medications that may affect cognitive or physical function, such as psychotropic drugs
- Have a history of carotid sinus sensitivity causing fainting or falls
- Have cancer and are undergoing radiation therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Hong Kong Polytechnic University, Department of Rehabilitation Sciences
Hong Kong, Hong Kong
Actively Recruiting
Research Team
J
JINGYI WU, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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