Actively Recruiting
A Causative Role for Amylin in Diabetic Peripheral Neuropathy
Led by Zabeen Mahuwala, MD · Updated on 2026-01-30
40
Participants Needed
2
Research Sites
569 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Three pieces of information lead to the basis for this study: 1. Individuals with Type-2 diabetes commonly develop peripheral neuropathy. 2. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. 3. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin. The purpose of this study is to determine whether a correlation exists between the amount of amylin present in the upper extremities of human subjects with Type-2 diabetes and the extent to which symptoms of peripheral neuropathy are expressed in those subjects. The investigators will be testing this by initially collecting blood and skin biopsy samples from subjects, followed by measuring patient sensation and pain responses to heat, cold, and pressure in the upper extremities.
CONDITIONS
Official Title
A Causative Role for Amylin in Diabetic Peripheral Neuropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject has been diagnosed with Type-2 Diabetes.
- Subject shows mild-to-severe peripheral neuropathy, as determined by Nerve Conduction Velocity (NCV) tests.
You will not qualify if you...
- Subject has not been diagnosed with Type-2 Diabetes.
- Subject shows average, or above average performance on Nerve Conduction Velocity (NCV) tests.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
UK Robert Straus Behavioral Science Laboratory
Lexington, Kentucky, United States, 40508
Active, Not Recruiting
2
University of Kentucky - Kentucky Neuroscience Institute
Lexington, Kentucky, United States, 40536
Actively Recruiting
Research Team
R
Rani Priyanka Vasireddy, MBBS, MHA
CONTACT
J
John T Slevin, M.D., M.B.A.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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