Actively Recruiting
CBT and the Neural Circuits of Anxiety
Led by UCLH/UCL Joint Research Office · Updated on 2025-06-29
174
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
Sponsors
U
UCLH/UCL Joint Research Office
Lead Sponsor
M
Medical Research Council
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions. This study aims to provide a theoretical model of the neurobiological mechanisms of CBT's therapeutic effect, where there currently is none, and potentially allow for more targeted/specific approaches to anxiety disorders following the identification of key CBT mechanisms. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.
CONDITIONS
Official Title
CBT and the Neural Circuits of Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Enrolled in IAPT Step 3 (high intensity service)
- Score of 8 or above on the GAD-7 indicating moderate anxiety
- Willing and able to provide written consent
You will not qualify if you...
- Score above 22 on the GAD-7
- Past or present psychotic disorder, bipolar disorder/mania, or alcohol/substance use disorder
- History of medical illness impairing cognitive function (e.g., serious head injury, endocrine disorder)
- Current use or use within 3 months of psychotropic medication such as SSRIs
- MRI contraindications including pacemaker, aneurysm clip, cochlear implant, neurostimulator, IUD, shrapnel, metal fragments in eye, weight over 250 lbs, or claustrophobia
- Females who are pregnant, planning pregnancy, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Cognitive Neuroscience, University College London
London, United Kingdom, WC1N 3AZ
Actively Recruiting
Research Team
E
Emily Lewis
CONTACT
O
Oliver Robinson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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