Measuring Immune Cell Responses in Adults with Cystic Fibrosis and Non-tuberculous Mycobacterial Lung Infection

What this Trial Is About

Researchers are evaluating a new diagnostic blood test for Non-Tuberculous Mycobacterial NTM infection in people with cystic fibrosis. This test measures the immune systems T cell response to the infection. The study aims to better understand how the body reacts to NTM in these patients by comparing those with and without infection. It is a multicenter case-control study focusing on T cell release of interferon-gamma as a marker of infection. The study involves one scheduled visit during routine cystic fibrosis care where a blood sample is taken. An additional 7 ml tube of blood will be collected to perform serology and culture tests. Patients are grouped based on positive or negative NTM serology and culture results. This approach allows researchers to assess cellular biomarkers linked to NTM infection. Participants will have their blood tested for the interferon-gamma release assay and T lymphocyte response during this single visit. The study measures the immune response to NTM antigens to provide more detailed diagnostic information than standard methods. The total participation involves just this one visit, which coincides with regular clinical care for cystic fibrosis.

Cellular Markers in Treated or Untreated Non-tuberculous Mycobacterial Respiratory Infection in Patients With Cystic Fibrosis