Actively Recruiting
Cervical Pre-cancer Treatment Failure Among Women Living With HIV in Zimbabwe
Led by University of Bern · Updated on 2025-10-02
250
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
U
University of Bern
Lead Sponsor
K
Krebsforschung Schweiz, Bern, Switzerland
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to improve cervical pre-cancer treatment outcomes among women living with HIV (WLWH), particularly in low and middle income countries (LMICs), by generating the evidence needed for post-treatment monitoring guidelines. The main questions it aims to answer are: * What is the risk of disease recurrence/persistence after cervical pre-cancer treatment among women living with HIV in Zimbabwe? * What is the predictive value of different human papillomavirus (HPV) and DNA methylation testing strategies for monitoring cervical disease recurrence/persistence after pre-cancer treatment? Participants will have cervical biopsies taken for histological assessment and cervical samples for HPV genotyping and DNA methylation testing. Researchers will follow all participating women every six months for 24 months to evaluate post-treatment monitoring and cervical disease outcomes.
CONDITIONS
Official Title
Cervical Pre-cancer Treatment Failure Among Women Living With HIV in Zimbabwe
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18-65 years
- Confirmed HIV positive status through medical records
- Positive high-risk HPV genotype test at previous cervical cancer screening
- Cervical pre-cancer treatment indicated by Newlands Clinic guidelines
- Signed informed consent
You will not qualify if you...
- History or suspicion of cervical cancer
- History of total hysterectomy (no cervix)
- Cervical pre-cancer treatment within the past 12 months
- Currently pregnant
AI-Screening
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Trial Site Locations
Total: 1 location
1
Women's Health Centre at Newlands Clinic
Harare, Zimbabwe
Actively Recruiting
Research Team
E
Eliane Rohner, MD, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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