Actively Recruiting
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Led by Seagen, a wholly owned subsidiary of Pfizer · Updated on 2026-05-11
1006
Participants Needed
159
Research Sites
458 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors. The study will have four parts. * Part A of the study will find out how much sigvotatug vedotin should be given to participants. * Part B will use the dose found in Part A to find out how safe sigvotatug vedotin is and if it works to treat solid tumors. * Part C of the study will find out how safe sigvotatug vedotin is in combination with these other drugs. * Part D will include people who have not received treatment. This part of the study will find out how safe sigvotatug vedotin is in combination with these other drugs and if these combinations work to treat solid tumors. * In Parts C and D, participants will receive sigvotatug vedotin with either: * Pembrolizumab or, * Pembrolizumab and carboplatin, or * Pembrolizumab and cisplatin.
CONDITIONS
Official Title
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a confirmed metastatic or unresectable solid tumor of one of these types: non-small cell lung cancer, head and neck squamous cell cancer, advanced HER2-negative breast cancer, esophageal squamous cell carcinoma, esophageal or gastro-esophageal junction adenocarcinoma, cutaneous squamous cell cancer, exocrine pancreatic adenocarcinoma, bladder cancer, cervical cancer, gastric cancer, or high grade serous ovarian cancer
- Part A: Disease must be relapsed, refractory, or intolerant to standard therapies without other options
- Part B: Must have relapsed or refractory disease, received platinum-based therapy and PD-1/PD-(L)1 inhibitor if available
- Part C: Eligible for pembrolizumab alone or with cisplatin or carboplatin; must be treatment-naïve for advanced or metastatic therapy
- Part D: Treatment-naïve for advanced or metastatic systemic therapy
- Participants in Parts B and D must have accessible tumor for biopsy and agree to biopsy; archival biopsy within 90 days allowed
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- Measurable disease per RECIST v1.1 at baseline
You will not qualify if you...
- History of another cancer within 3 years or residual disease from prior malignancy, except low-risk cancers
- Active central nervous system metastases, unless stable and off corticosteroids for 7 days; small untreated asymptomatic CNS metastases allowed in Part D
- Carcinomatous meningitis
- Previous treatment with MMAE-containing agents or integrin beta-6 targeting agents
- Pre-existing neuropathy Grade 1 or higher for cisplatin/carboplatin groups; Grade 2 or higher for other groups
- Uncontrolled serious infections within 2 weeks before starting study drug
- Severe lung disease (Grade 3 or higher) unrelated to cancer
- Prior immune therapy discontinued due to severe immune-related side effects (Parts C and D)
- History or current interstitial lung disease or pneumonitis requiring steroids or suspected but not ruled out
- Lung function with diffusing capacity (DLCO) less than 50% predicted
- Investigator site staff and immediate family members involved in the study conduct or sponsorship
AI-Screening
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Trial Site Locations
Total: 159 locations
1
Alaska Oncology and Hematology
Anchorage, Alaska, United States, 99508
Actively Recruiting
2
Highlands Oncology Group
Fayetteville, Arkansas, United States, 72703
Actively Recruiting
3
Highlands Oncology Group
Rogers, Arkansas, United States, 72758
Actively Recruiting
4
Highlands Oncology Group
Springdale, Arkansas, United States, 72762
Actively Recruiting
5
Providence Medical Foundation
Anaheim, California, United States, 92805
Actively Recruiting
6
Providence Medical Foundation
Fullerton, California, United States, 92835
Actively Recruiting
7
Providence St. Jude Medical Center Virginia K Crosson and Infusion Center
Fullerton, California, United States, 92835
Actively Recruiting
8
Cancer and Blood Research Center, LLC
Los Alamitos, California, United States, 90720
Not Yet Recruiting
9
Cancer and Blood Specialty Clinic
Los Alamitos, California, United States, 90720
Not Yet Recruiting
10
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
Actively Recruiting
11
The Regents of the University of California
Los Angeles, California, United States, 90095
Actively Recruiting
12
UCLA Department of Medicine-Hematology/Oncology
Los Angeles, California, United States, 90095
Actively Recruiting
13
UCLA Department of Medicine - Hematology & Oncology
Santa Monica, California, United States, 90404
Actively Recruiting
14
Cancer AND Blood Specialty Clinic
Torrance, California, United States, 90505
Not Yet Recruiting
15
American Oncology Partners, PA. a Florida professional service corporation, d/b/a Vista Oncology
Fort Myers, Florida, United States, 33913
Actively Recruiting
16
Florida Cancer Specialists & Research Institute, LLC
Fort Myers, Florida, United States, 33916
Actively Recruiting
17
Memorial Cancer Institute
Hollywood, Florida, United States, 33021
Actively Recruiting
18
Memorial Healthcare System
Hollywood, Florida, United States, 33021
Actively Recruiting
19
Florida Cancer Specialists
Orlando, Florida, United States, 32827
Actively Recruiting
20
Memorial Cancer Institute at Memorial Hospital West
Pembroke Pines, Florida, United States, 33028
Actively Recruiting
21
Memorial Hospital West
Pembroke Pines, Florida, United States, 33028
Actively Recruiting
22
Ingalls Family Care Center
Calumet City, Illinois, United States, 60409
Actively Recruiting
23
UChicago Medicine - River East
Chicago, Illinois, United States, 60611
Actively Recruiting
24
The University Of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
25
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
26
UChicago Medicine at Ingalls - Flossmoor
Flossmoor, Illinois, United States, 60422
Actively Recruiting
27
UChicago Medicine Ingalls Memorial
Harvey, Illinois, United States, 60426
Actively Recruiting
28
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
New Lenox, Illinois, United States, 60451
Actively Recruiting
29
The University of Chicago Medicine Center for Advanced Care Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
30
Southern Illinois University - Simmons Cancer Institute
Springfield, Illinois, United States, 62702
Actively Recruiting
31
Springfield Clinic Radiology - 800 Building
Springfield, Illinois, United States, 62702
Actively Recruiting
32
Springfield Clinic Urgent Care Plus
Springfield, Illinois, United States, 62702
Actively Recruiting
33
Springfield Clinic
Springfield, Illinois, United States, 62702
Actively Recruiting
34
Springfield Clinic Main Campus
Springfield, Illinois, United States, 62703
Actively Recruiting
35
Springfield Clinic Radiology - Main Campus
Springfield, Illinois, United States, 62703
Actively Recruiting
36
Springfield Memorial Hospital
Springfield, Illinois, United States, 62781
Actively Recruiting
37
UChicago Medicine at Ingalls - Tinley Park
Tinley Park, Illinois, United States, 60477
Actively Recruiting
38
UChicago Medicine - Northwest Indiana
Crown Point, Indiana, United States, 46307
Actively Recruiting
39
Fort Wayne Medical Oncology and Hematology, Inc
Fort Wayne, Indiana, United States, 46804
Actively Recruiting
40
Community Health Network, Inc
Indianapolis, Indiana, United States, 46219
Actively Recruiting
41
Community Health Network, Inc.
Indianapolis, Indiana, United States, 46227
Actively Recruiting
42
Community Health Network Investigational Drug Services
Indianapolis, Indiana, United States, 46250
Actively Recruiting
43
Community Health Network, Inc.
Indianapolis, Indiana, United States, 46250
Actively Recruiting
44
The University of Kansas Cancer Center, Investigational Drug Services
Fairway, Kansas, United States, 66205
Actively Recruiting
45
The University of Kansas Clinical Research Center
Fairway, Kansas, United States, 66205
Actively Recruiting
46
The University of Kansas Hospital
Kansas City, Kansas, United States, 66160
Actively Recruiting
47
The University of Kansas Medical Center Medical Office Building
Kansas City, Kansas, United States, 66160
Actively Recruiting
48
University of Kansas Hospital Cambridge North Tower A
Kansas City, Kansas, United States, 66160
Actively Recruiting
49
University of Kansas Medical Center Research Institute
Kansas City, Kansas, United States, 66160
Actively Recruiting
50
The University of Kansas Cancer Center - Indian Creek Campus
Overland Park, Kansas, United States, 66211
Actively Recruiting
51
The University of Kansas Cancer Center - Westwood
Westwood, Kansas, United States, 66205
Actively Recruiting
52
University of Kansas Cancer Center
Westwood, Kansas, United States, 66205
Actively Recruiting
53
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
54
Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
55
Beth Israel Deaconess Medical Center,East Campus Research Pharmacy
Boston, Massachusetts, United States, 02215
Actively Recruiting
56
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
57
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
58
Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts, United States, 02467
Actively Recruiting
59
Allina Health Cancer Institute - Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
60
Allina Health Cancer Institute - Abbott Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
61
Allina Health Cancer Institute
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
62
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, United States, 89169
Actively Recruiting
63
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Babylon, New York, United States, 11702
Actively Recruiting
64
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Brooklyn, New York, United States, 11210
Actively Recruiting
65
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
New Hyde Park, New York, United States, 11042
Actively Recruiting
66
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
New York, New York, United States, 10028
Actively Recruiting
67
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
68
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Patchogue, New York, United States, 11772
Actively Recruiting
69
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Port Jefferson Station, New York, United States, 11776
Actively Recruiting
70
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Riverhead, New York, United States, 11901
Actively Recruiting
71
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
Shirley, New York, United States, 11967
Actively Recruiting
72
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
The Bronx, New York, United States, 10469
Actively Recruiting
73
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Active, Not Recruiting
74
OU Health University of Oklahoma Medical Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
75
Stephenson Cancer Center (chemo location)
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
76
University of Oklahoma Health Science Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
77
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
78
Providence Oncology and Hematology Care Clinic - Westside
Portland, Oregon, United States, 97225
Actively Recruiting
79
Providence St. Vincent Medical Center- Investigational Drug Services
Portland, Oregon, United States, 97225
Actively Recruiting
80
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
81
Sanford Cancer Center
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
82
Sanford USD Medical Center
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
83
US Oncology Research LLC
Nashville, Tennessee, United States, 37203
Actively Recruiting
84
Oncology Consultants, PA
Houston, Texas, United States, 77024
Actively Recruiting
85
Oncology Consultants, PA.
Houston, Texas, United States, 77030
Actively Recruiting
86
The University of Texas M.D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
87
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States, 75063
Actively Recruiting
88
Houston Medical Imaging
Pearland, Texas, United States, 77581
Not Yet Recruiting
89
South Texas Accelerated Research Therapeutics, LLC
San Antonio, Texas, United States, 78229
Active, Not Recruiting
90
UT Health East Texas HOPE Cancer Center
Tyler, Texas, United States, 75701
Actively Recruiting
91
UT Health East Texas Hope Cancer Center
Tyler, Texas, United States, 75708
Actively Recruiting
92
Tranquil Clinical Research
Webster, Texas, United States, 77598
Not Yet Recruiting
93
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
94
Northwest Medical Specialities. PLLC
Bonney Lake, Washington, United States, 98391
Not Yet Recruiting
95
Swedish Cancer Institute - Edmonds Campus
Edmonds, Washington, United States, 98026
Actively Recruiting
96
Swedish Cancer Institute Edmonds Campus
Edmonds, Washington, United States, 98026
Actively Recruiting
97
Northwest Medical Specialities.PLLC
Federal Way, Washington, United States, 98003
Not Yet Recruiting
98
Northwest Medical Specialities. PLLC
Gig Harbor, Washington, United States, 98332
Not Yet Recruiting
99
American Oncology Network Vista Oncology Division-West office
Olympia, Washington, United States, 98502
Actively Recruiting
100
American Oncology Network Vista Oncology Division-East office
Olympia, Washington, United States, 98506
Actively Recruiting
101
Northwest Medical Specialties, PPLC
Puyallup, Washington, United States, 98373
Not Yet Recruiting
102
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Actively Recruiting
103
Swedish Medical Center
Seattle, Washington, United States, 98122
Actively Recruiting
104
Exigent Research, LLC
Tacoma, Washington, United States, 98405
Actively Recruiting
105
Northwest Medical Specialities, PLLC
Tacoma, Washington, United States, 98405
Not Yet Recruiting
106
Center Hospitalier Universitaire d' Angers
Angers, France, 49100
Active, Not Recruiting
107
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne
Nice, France, 06189
Actively Recruiting
108
Centre Hospitalier Universitaire de Poitiers
Poitiers, France, 86021
Actively Recruiting
109
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France, 54519
Actively Recruiting
110
Institut Gustave Roussy Department de Pharmacie Clinique(-1)
Villejuif, France, 94805.
Actively Recruiting
111
lnstitut Gustave Roussy, Departement d'lnnovation Therapeutique et d'Essais Precoces (DITEP)
Villejuif, France, 94805.
Actively Recruiting
112
National Cancer Center
Goyang-si, Gyeonggi-do, South Korea, 10408
Actively Recruiting
113
Chungbuk National University Hospital
Cheongju-si, North Chungcheong, South Korea, 28644
Actively Recruiting
114
Severance Hospital Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
115
Samsung Medical Center
Seoul, South Korea, 06351
Not Yet Recruiting
116
The Catholic University of Korea
Seoul, South Korea, 06591
Actively Recruiting
117
Seoul Metropolitan Government Seoul National University Boramae Medical Center
Seoul, South Korea, 07061
Actively Recruiting
118
Korea University Guro Hospital
Seoul, South Korea, 08308
Actively Recruiting
119
Farmacia Ensayos Hospital HM Universitario Sanchinarro
Madrid, Agrigento, Spain, 28050
Actively Recruiting
120
Elche General University Hospital
Elche, Alicante, Spain, 03203
Actively Recruiting
121
Equipo de Farmacia Oncológica- Ensayos Clínicos Servicio de Farmacia Hospital Universitario Marqués
Santander, Cantabria, Spain, 39008
Actively Recruiting
122
Hospital Universitario Marques de Valdecilla
Santander, Cantabria, Spain, 39008
Actively Recruiting
123
Hospital HM Nou Delfos
Barcelona, Catalonia, Spain, 08023
Actively Recruiting
124
Fundación Privada Instituto de Investigación Oncológica de Vall Hebron
Barcelona, Other, Spain, 08035
Actively Recruiting
125
NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona
Barcelona, OTH, Spain, 08023
Actively Recruiting
126
Elche General University Hospital
Elche, Valencia, Spain, 03203
Actively Recruiting
127
Hospital General Universitario de Elche
Elche, Valencia, Spain, 03203
Actively Recruiting
128
Farmacia Ensayos clínicos, Unidad START Barcelona
Barcelona, Spain, 08023
Actively Recruiting
129
Hospital HM Nou Delfos - START Barcelona
Barcelona, Spain, 08023
Actively Recruiting
130
Hospital Quiron Salud Barcelona
Barcelona, Spain, 08023
Actively Recruiting
131
NEXT Oncology - IOB Hospital Quironsalud Barcelona
Barcelona, Spain, 08023
Actively Recruiting
132
Area general-Planta Baixa | Unitat d'investigacio en terapia Molecular del Cancer "la Caixa"
Barcelona, Spain, 08035
Actively Recruiting
133
Hospital Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
134
Elche General University Hospital
Elche, Spain, 03203
Actively Recruiting
135
Hospital Universitario De Jerez
Jerez de la Frontera, Spain, 10407
Actively Recruiting
136
UGC Farmacia Ensayos clinicos - Hospital Universitario de Jerez
Jerez de la Frontera, Spain, 10407
Actively Recruiting
137
Hospital Universitario de Jerez
Jerez de la Frontera, Spain, 11407
Actively Recruiting
138
Fundación de Investigación Hm Hospitales, C.I.F. G-83643841
Madrid, Spain, 28015
Actively Recruiting
139
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
140
Servicio de Radiologia Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
141
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
142
Hospital Universitario 12 Octubre
Madrid, Spain, 28041
Actively Recruiting
143
Hospital HM Sanchinarro, START-Madrid-CIOCC
Madrid, Spain, 28050
Actively Recruiting
144
Quironsalud Malaga
Málaga, Spain, 129004
Actively Recruiting
145
Kantonsspital Graubunden
Chur, Switzerland, 7000
Actively Recruiting
146
University Hospital Lausanne CHUV
Lausanne, Switzerland, 1011
Actively Recruiting
147
CHUV - Service de pharmacie BH-04, Essais cliniques
Lausanne, Switzerland, CH-1011
Actively Recruiting
148
Kaohsiung Medical University Hospital
Kaohsiung City, R.o.c., Taiwan, 80756
Actively Recruiting
149
National Taiwan University Hospital
Taipei, Taiwan, 100, R.O.C
Not Yet Recruiting
150
Taipei Veterans General Hospital.
Taipei, Taiwan, 11217
Actively Recruiting
151
The Royal Marsden Hospital (Surrey)
Sutton, Queensland, United Kingdom, SM2 5PT
Actively Recruiting
152
Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
153
Queen Elizabeth Hospital
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
154
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
155
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW3 6JJ
Actively Recruiting
156
Sarah Cannon Research Institute
London, United Kingdom, W1G 6AD
Actively Recruiting
157
Diagnostic centre
London, United Kingdom, W1G 7AF
Actively Recruiting
158
The Harley Street Clinic
London, United Kingdom, W1G 8BJ
Actively Recruiting
159
Radiology
London, United Kingdom, W1G 8PP
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
5
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