Characterization of Exosomes Platelets-released

What this Trial Is About

Researchers are studying platelet-derived extracellular vesicles (PEVs), which are tiny particles released by cells that play important roles in cell communication and may serve as biomarkers for clinical diagnostics. This observational study focuses on understanding the characteristics of platelet exosomes and how antiplatelet agents affect their release and composition, especially in relation to cardiovascular disease. The study is conducted across multiple centers involving healthy adult volunteers without known pathologies. Participants include 54 subjects from one center and 121 buffy coat samples from another. Biographical and body measurement data will be collected along with fasting blood samples drawn from the antecubital vein for hematochemical and research analyses. The primary outcomes involve detailed characterization of exosomes released by activated platelets through nanoparticle tracking analysis and proteomic studies over 36 months. Secondary outcomes will explore how these exosome profiles relate to the participants' demographic and physical data. Throughout the study, participants will undergo blood sampling and data collection to monitor platelet exosome characteristics. Researchers will analyze these samples using advanced laboratory techniques. The study will provide insights into platelet exosome profiles and their possible links to health, with safety ensured by excluding individuals with various diseases or recent medical events. The study will last for up to 40 months, including follow-up analyses of collected data.

Characterization of Exosomes Platelets-released