Actively Recruiting
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-02-07
700
Participants Needed
3
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging techniques that may provide insights into the underlying disease mechanisms. By understanding these markers, the investigators hope to improve the way the investigators diagnose and manage CMP, particularly in terms of predicting progression to heart failure or heart transplantation. The study will evaluate patients with hypertrophic cardiomyopathy (e.g., sarcomeric forms, Anderson-Fabry disease, AL, and TTR cardiac amyloidosis), dilated cardiomyopathy and arrhythmogenic cardiomyopathy. These patients will undergo clinical evaluations, including ECG, echocardiograms, CMR, biopsy analysis, and genetic testing, as well as molecular studies such as transcriptomics and miRNA analysis. This comprehensive approach aims to identify potential new biomarkers for diagnosing and predicting the disease course.
CONDITIONS
Official Title
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with CMP according to current international guidelines
- Age 212 years at the time of diagnosis
- Obtaining informed consent from the patient and the parent or legal guardian (in the case of patients aged < 18 years)
You will not qualify if you...
- none
AI-Screening
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Trial Site Locations
Total: 3 locations
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Emilia-Romagna/Bologna, Italy, 40138
Actively Recruiting
2
Dipartimento di Scienze Toraciche Cardiovascolari, Fondazione Policlinico Universitario A. Gemelli IRCSS di Roma
Roma, Lazio/Roma, Italy, 00161
Not Yet Recruiting
3
Azienda Ospedaliero-Universitaria Careggi di Firenze
Florence, Toscana/Firenze, Italy, 50134
Not Yet Recruiting
Research Team
E
Elena Biagini, MD, PhD
CONTACT
S
Silvia Palmieri, M. Sc.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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