The Effect of Chronic Cerebral Hypoperfusion on Amyloid-β Metabolism in a Transgenic Mouse Model of Alzheimer's Disease (PS1V97L).
Heyun Yang, Tingting Hou, Wei Wang...
https://pubmed.ncbi.nlm.nih.gov/29614686Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID03657732
A Multi-center Longitudinal Cohort Study of Familial Alzheimer's Disease in China
Led by Capital Medical University · Updated on 2026-03-23
40000
Participants Needed
65
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Capital Medical University
Lead Sponsor
B
Beijing Tiantan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are establishing and continuously improving a nationwide research network focused on Familial Alzheimer's Disease (FAD) in China. This observational study collects detailed information on family demographics, genetics, neuropsychology, neuroimaging, and biomarkers to better understand FAD's genetic features, disease progression, and diagnosis and treatment status in the Chinese population. The study aims to clarify epidemiological and clinical characteristics of FAD, discover early diagnostic biomarkers, and develop a genetic counseling model. The study includes cohorts with known mutations in PSEN1, PSEN2, and APP genes, including both mutation carriers and noncarriers, presymptomatic and symptomatic individuals, as well as normal cognitive control participants. It involves comprehensive epidemiological surveys across different nationalities and regions in China, regular collection and follow-up of biological samples like blood, urine, and saliva, and data including neuropsychology and imaging. The project uses advanced imaging methods such as structural MRI and PET scans to monitor brain changes and biomarkers at different stages of Alzheimer's progression. Participants will undergo regular assessments including neuropsychological tests, brain imaging, and biomarker analysis to track disease development over time. The study measures the prevalence of gene mutations and patterns of genetic, biofluid, imaging, and cognitive markers over multiple years. It also evaluates changes in brain structure, metabolism, amyloid and tau deposition, and tests non-drug interventions. The total participation duration varies, with some measures assessed yearly for up to 10 years, supporting long-term monitoring and data collection.
CONDITIONS
Brief Title
The Chinese Familial Alzheimer's Network
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Written informed consent obtained from the participant or a legal guardian before any study procedures
- At least two first-degree relatives in a family have Alzheimer's disease, with patients in at least two generations
- At least one family member with normal cognitive function older than the family's average age of onset
- Pedigrees carrying FAD pathogenic genes (APP, PSEN1, PSEN2)
- Participants are older than 18 years
- Participants may be cognitively normal or have dementia but not bedridden
- Ability to provide two reliable informants who can supply clinical information
- Dementia diagnosed using DSM-IV-R criteria
- Alzheimer's diagnosis based on NINCDS-ADRDA or NIA-AA criteria
- Mild cognitive impairment diagnosed according to Petersen criteria and Lopez classification
You will not qualify if you...
- Dementia caused by other conditions such as depression, psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, AIDS, Creutzfeldt-Jakob disease, vascular dementia, frontotemporal dementia, dementia with Lewy bodies, or Parkinson's dementia
- MRI and lab tests that do not support an Alzheimer's diagnosis
- Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases, or cancer
- Severe psychiatric illness or severe dementia interfering with assessments
- History of alcoholism or drug abuse
- Pregnant or lactating women
- No reliable informants available
- Lumbar puncture contraindications such as coagulation disorders, recent lumbar surgery, or repeated cerebrospinal fluid leakage
- MRI contraindications including electronic or magnetic metal implants, metallic eye foreign bodies, or brain aneurysm clips
- For normal controls: abnormal cognitive test scores, history of brain injury or infarction, neurological or systemic diseases causing cognitive impairment, mental retardation, refusal of blood draw, MRI contraindications, or refusal to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - 3 to 10 years
Participants are regularly followed over multiple years to collect biological samples and data including neuropsychology assessments and imaging, tracking changes from asymptomatic to symptomatic stages.
Annual visits for up to 10 years
Trial Site Locations
Total: 65 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Actively Recruiting
2
Beijing Geriatric Hospital
Changping, Beijing Municipality, China
Actively Recruiting
3
Beijing Chao Yang Hospital
Chaoyang, Beijing Municipality, China
Actively Recruiting
4
China-Japan Friendship Hospital
Chaoyang, Beijing Municipality, China
Actively Recruiting
5
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Fengtai, Beijing Municipality, China
Actively Recruiting
6
Chinese PLA General Hospital
Haidian, Beijing Municipality, China
Actively Recruiting
7
Fu Xing Hospital, Capital Medical University
Haidian, Beijing Municipality, China
Actively Recruiting
8
Peking University Third Hospital
Haidian, Beijing Municipality, China
Actively Recruiting
9
Peking Union Medical College Hospital
Xicheng, Beijing Municipality, China
Actively Recruiting
10
Peking University First Hospital
Xicheng, Beijing Municipality, China
Actively Recruiting
11
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Yuzhong, Chongqing Municipality, China
Actively Recruiting
12
The Second Affiliated Hospital of Chongqing Medical University
Yuzhong, Chongqing Municipality, China
Actively Recruiting
13
Fujian Medical University Union Hospital
Fujian, Guangdong, China
Actively Recruiting
14
Guangzhou Psychiatric Hospital
Guangzhou, Guangdong, China
Actively Recruiting
15
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Zhongshan, Guangdong, China
Actively Recruiting
16
First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Actively Recruiting
17
The Affiliated Hospital Of Guizhou Medical University
Guiyang, Guizhou, China
Actively Recruiting
18
Handan Central Hospital
Handan, Hebei, China
Actively Recruiting
19
First Hospital of Shijiazhuang City
Shijiazhuang, Hebei, China
Actively Recruiting
20
Tangshan Worker's Hospital
Tangshan, Hebei, China
Actively Recruiting
21
Hebei General Hospital
Zhijiazhuang, Hebei, China
Actively Recruiting
22
First Affiliated Hospital of Harbin Medical University
Haerbin, Heilongjiang, China
Actively Recruiting
23
Kaifeng Central Hospital
Kaifeng, Henan, China
Actively Recruiting
24
Henan Provincial People's Hospital
Zhengzhou, Henan, China
Actively Recruiting
25
People's Hospital of Zhengzhou
Zhengzhou, Henan, China
Actively Recruiting
26
People's Hospital Affiliated Hubei Medical University
Wuhan, Hubei, China
Actively Recruiting
27
Tongji Hospital
Wuhan, Hubei, China
Actively Recruiting
28
The Third Xiangya Hospital of Central South University
Wuhan, Hunan, China
Actively Recruiting
29
Wuhan University Zhongnan Hospital
Wuhan, Hunan, China
Actively Recruiting
30
Xiangya Hospital of Central South University
Wuhan, Hunan, China
Actively Recruiting
31
Nantong University Affiliated Hospital
Nantong, Jiangsu, China
Actively Recruiting
32
Subei People's Hospital of Jiangsu
Subei, Jiangsu, China
Actively Recruiting
33
Mineral General Hospital, Xuzhou
Xuzhou, Jiangsu, China
Actively Recruiting
34
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, China
Actively Recruiting
35
China-Japan friendship Hospital of Jilin university
Changchun, Jilin, China
Actively Recruiting
36
The First Hospital of Jilin University
Changchun, Jilin, China
Actively Recruiting
37
Changda Hospital, Anshan
Anshan, Liaoning, China
Actively Recruiting
38
Affiliated Zhongshan hospital of Dalian university
Dalian, Liaoning, China
Actively Recruiting
39
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
Actively Recruiting
40
First Hospital of China Medical University
Shenyang, Liaoning, China
Actively Recruiting
41
Baotou Central Hospital
Baotou, Nei Monggol, China
Actively Recruiting
42
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Actively Recruiting
43
The People's Hospital of Ningxia
Yinchuan, Ningxia, China
Actively Recruiting
44
Qilu Hospital of Shandong University
Jinan, Shandong, China
Actively Recruiting
45
Shandong Provincial Hospital
Jining, Shandong, China
Actively Recruiting
46
Qilu Hospital of Shandong University (Qingdao)
Qingdao, Shandong, China
Actively Recruiting
47
QingDao Municipal Hospital
Qingdao, Shandong, China
Actively Recruiting
48
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Actively Recruiting
49
The 88th Hospital of PLA
Tai’an, Shandong, China
Actively Recruiting
50
Shanghai Changzheng Hospital
Huangpu, Shanghai Municipality, China
Actively Recruiting
51
Ruijin Hospital
Luwan, Shanghai Municipality, China
Actively Recruiting
52
RenJi Hospital
Putong, Shanghai Municipality, China
Actively Recruiting
53
The First Affiliated Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Actively Recruiting
54
First Affiliated Hospital Xi'an Jiaotong University
Xi’an, Shanxi, China
Actively Recruiting
55
Tang-Du Hospital
Xi’an, Shanxi, China
Actively Recruiting
56
Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
Actively Recruiting
57
Zigong First People's Hospital
Zigong, Sichuan, China
Actively Recruiting
58
Tianjin Huanhu Hospital
Xianshuigu, Tianjin Municipality, China
Actively Recruiting
59
Tianjin Medical University General Hospital
Xiaobailou, Tianjin Municipality, China
Actively Recruiting
60
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Ürümqi, Xinjiang, China
Actively Recruiting
61
First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
62
Shao Yifu Hospital of Zhejiang Medical University
Hangzhou, Zhejiang, China
Actively Recruiting
63
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
64
Ningbo City Medical Treatment Center Lihuili Hospital
Ningbo, Zhejiang, China
Actively Recruiting
65
First Affiliated Hospital of Wenzhou Medical Univeristy
Wenzhou, Zhejiang, China
Actively Recruiting
Loading map...
Research Team
J
Jianping Jia, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer's Disease (PS1V97L) Transgenic Mice.
Ting-Ting Hou, He-Yun Yang, Wei Wang...
https://pubmed.ncbi.nlm.nih.gov/29614663A Novel AβPP M722K Mutation Affects Amyloid-β Secretion and Tau Phosphorylation and May Cause Early-Onset Familial Alzheimer's Disease in Chinese Individuals.
Qianqian Wang, Jianping Jia, Wei Qin...
https://pubmed.ncbi.nlm.nih.gov/26402764Diagnosis and treatment of dementia in neurology outpatient departments of general hospitals in China.
Jianping Jia, Xiumei Zuo, Xiang-Fei Jia...
https://pubmed.ncbi.nlm.nih.gov/26256457Brain Amyloid-β Plays an Initiating Role in the Pathophysiological Process of the PS1V97L-Tg Mouse Model of Alzheimer's Disease.
Wei Wang, Lu Lu, Qiao-Qi Wu...
https://pubmed.ncbi.nlm.nih.gov/27079718A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.
Jing Dong, Wei Qin, Cuibai Wei...
https://pubmed.ncbi.nlm.nih.gov/28269784Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease.
Guili Zhang, Yunyan Xie, Wei Wang...
https://pubmed.ncbi.nlm.nih.gov/27838006Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.
Yue Wang, Zhe Cheng, Wei Qin...
https://pubmed.ncbi.nlm.nih.gov/21929538Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.
Wei Qin, Jianping Jia
https://pubmed.ncbi.nlm.nih.gov/18445230Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.
Boyan Fang, Longfei Jia, Jianping Jia
https://pubmed.ncbi.nlm.nih.gov/16916581