Actively Recruiting
Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI)
Led by Johns Hopkins Bloomberg School of Public Health · Updated on 2025-12-02
3140
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins Bloomberg School of Public Health
Lead Sponsor
R
Research Training and Management International (RTMI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI) to reduce cholera infections and promote lasting WASH behaviors in areas near cholera cases in Bangladesh. Cholera causes millions of infections globally each year, and this study focuses on people living close to cholera patients who are at much higher risk during the first week after the patient receives care. The study aims to find scalable ways to deliver effective WASH interventions to these high-risk communities. The study involves three phases: development and planning of the intervention using interviews and pilot testing, implementation and evaluation through a randomized controlled trial, and dissemination of findings for policy planning. Participants in the trial will be divided into two groups. One group receives the usual advice on oral rehydration and a WASH leaflet during a single visit. The other group participates in group sessions led by a health promoter who teaches about diarrhea spread, handwashing, water treatment, and safe water storage. These households also receive a cholera prevention package and weekly voice and text messages for 12 months promoting WASH behaviors. Water and clinical samples will be analyzed to study cholera transmission. Participants will be followed for one month to track new cholera infections and for 12 months to observe diarrhea cases and WASH behaviors. Data collected includes handwashing frequency, water quality, psychosocial factors, and child growth assessments. The study measures the number of cholera infections in the participant rings around cholera cases as the primary outcome. Safety monitoring and long-term follow-up are integrated throughout the trial, which is expected to provide important evidence on controlling cholera through targeted WASH interventions.
CONDITIONS
Brief Title
Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Index cholera patient have no running water inside of their home
You will not qualify if you...
- No one will be excluded because of age, sex, religion, or sexual preference
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 months
Participants receive the CHoBI7 Water, Sanitation, and Hygiene intervention through group sessions led by a health promoter, including a cholera prevention package, followed by weekly voice and text messages for 12 months to encourage recommended WASH behaviors.
1 group session visit and weekly follow-up messages over 12 months
Duration - Single visit
Participants receive standard messages on oral rehydration solution use provided at a single visit for diarrhea patients discharged from the health facility.
1 visit (in-person)
Duration - 12 months
Participants are followed for cholera infections, diarrhea incidence, handwashing behavior, water quality, and child development outcomes over 12 months.
Periodic assessments during the 12-month follow-up
Trial Site Locations
Total: 2 locations
1
International Centre for Diarrhoeal Disease Research, Bangladesh
Dhaka, Bangladesh
Actively Recruiting
2
Research Training and Management International
Dhaka, Bangladesh
Actively Recruiting
Research Team
C
Christine Marie George, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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