Study of Circulating Tumour DNA and Imaging Features in Patients with Colorectal Cancer Undergoing Surgery

What this Trial Is About

Researchers are conducting an observational study to explore the relationship between circulating tumour DNA ctDNA and imaging features of extramural venous invasion EMVI in patients with colorectal adenocarcinoma. The study aims to determine if vascular spread contributes to metastatic disease by linking EMVI status with ctDNA levels. Participants include patients with colorectal cancer who have no metastases and are eligible for curative surgery. The study involves collecting two blood samples from each patient one before surgery and another during or within 24 hours after surgery. Patients are grouped based on their EMVI status from MRI scans before and after chemoradiotherapy. The research team monitors ctDNA changes related to EMVI and follows patient survival outcomes over time. Participants undergo a pre-operative staging scan within six weeks before surgery and provide blood samples as described. They are followed annually for up to three years to assess ctDNA, EMVI status, and survival outcomes. The primary outcome is to examine the link between EMVI and ctDNA over two years, with additional measures including ctDNA changes during surgery and survival tracked at 1, 2, and 3 years.

Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion