Actively Recruiting
Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)
Led by Yaou Liu · Updated on 2026-03-09
70000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary central nervous system (CNS) tumors mostly occur in the brain, with gliomas being the most common malignant type and glioblastomas the most aggressive. This research project aims to create a large, standardized database combining clinical details, preoperative MRI scans, and molecular pathology results for over 50,000 CNS tumor cases, including 10,000 gliomas. It also includes a prospective glioma database with advanced MRI sequences and follow-up data to help improve diagnosis and treatment evaluation. The project involves collecting and integrating detailed clinical information, imaging, and pathology results to form a high-quality, large-capacity database tailored to Chinese patients and clinical standards. It establishes protocols for MRI image acquisition, tumor classification, and database management. The study does not intervene in treatment but focuses on data collection from retrospective and prospective cohorts. Participants provide MRI scans and clinical data, including pathology results, which are used to build and update the database continuously. Researchers will analyze these data to develop classification and grading standards, prognosis criteria, and treatment evaluation systems. The study includes long-term follow-up and aims to support large-scale research, with outcomes measured by the establishment of standardized databases and predictive models for glioma patient molecular and survival outcomes.
CONDITIONS
Brief Title
Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 90 years
- Confirmed diagnosis of glioma based on pathological results
- Complete MRI sequences without obvious artifacts
- Patient signs an informed consent form
You will not qualify if you...
- Having other neurological diseases
- Prior surgery, biopsy, radiation therapy, or chemotherapy before enrollment
- Unable to complete clinical scoring, laboratory tests, or follow-up
- Unable to tolerate MRI examination or poor image quality due to motion artifacts
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies based on individual diagnostic processes
Participants undergo clinical assessments and MRI scans to confirm and characterize brain tumors.
1 to 2 visits depending on diagnostic procedures
Duration - Up to 8 years
Participants are followed over time to collect clinical, imaging, and molecular data for research purposes.
Periodic visits according to clinical and research schedules
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
Research Team
Y
Yaou Liu, Doctor
J
Junjie Li, Master
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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