HOPE Study Building a Large Brain Tumor Database Using MRI and Molecular Data Observing Glioma and Other Brain Cancers in Adults Aged 18 to 90

What this Trial Is About

Primary central nervous system CNS tumors mostly occur in the brain, with gliomas being the most common malignant type and glioblastomas the most aggressive. This research project aims to create a large, standardized database combining clinical details, preoperative MRI scans, and molecular pathology results for over 50,000 CNS tumor cases, including 10,000 gliomas. It also includes a prospective glioma database with advanced MRI sequences and follow-up data to help improve diagnosis and treatment evaluation. The project involves collecting and integrating detailed clinical information, imaging, and pathology results to form a high-quality, large-capacity database tailored to Chinese patients and clinical standards. It establishes protocols for MRI image acquisition, tumor classification, and database management. The study does not intervene in treatment but focuses on data collection from retrospective and prospective cohorts. Participants provide MRI scans and clinical data, including pathology results, which are used to build and update the database continuously. Researchers will analyze these data to develop classification and grading standards, prognosis criteria, and treatment evaluation systems. The study includes long-term follow-up and aims to support large-scale research, with outcomes measured by the establishment of standardized databases and predictive models for glioma patient molecular and survival outcomes.

Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)