Actively Recruiting
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-11
675
Participants Needed
153
Research Sites
356 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation. The goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.
CONDITIONS
Official Title
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has nonsquamous NSCLC (Stage IIIB, Stage IIIC) not eligible for curative resection or chemoradiation or Stage IV: M1a, M1b, or M1c
- If HIV positive, must have well controlled HIV on antiretroviral therapy (ART)
You will not qualify if you...
- Has diagnosis of small cell lung cancer or presence of small cell elements in mixed tumors
- Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease
- Has uncontrolled, significant cardiovascular or cerebrovascular disease
- Has a gastrointestinal disorder affecting absorption
- Is HIV positive with history of Kaposi's sarcoma or Multicentric Castleman's Disease
- Has received prior systemic anticancer therapy for advanced or metastatic NSCLC
- Has known additional malignancy progressing or treated within past 3 years
- Has known active central nervous system metastases or carcinomatous meningitis
- Has active autoimmune disease requiring systemic treatment in past 2 years
- Has history or current pneumonitis/interstitial lung disease requiring steroids
- Has active infection requiring systemic therapy except those specified by protocol
- Has history of stem cell or solid organ transplant
- Has not adequately recovered from major surgery or has ongoing surgical complications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 153 locations
1
Central Alabama Research ( Site 0108)
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
Stamford Hospital ( Site 0126)
Stamford, Connecticut, United States, 06902
Actively Recruiting
3
Mount Sinai Cancer Center ( Site 0137)
Miami Beach, Florida, United States, 33140
Completed
4
Indiana University Health Arnett Cancer Center ( Site 0116)
Lafayette, Indiana, United States, 47904
Actively Recruiting
5
New England Cancer Specialists ( Site 0139)
Westbrook, Maine, United States, 04092
Actively Recruiting
6
New York Oncology Hematology, P.C. ( Site 0119)
Albany, New York, United States, 12206
Actively Recruiting
7
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0111)
Lancaster, Pennsylvania, United States, 17601
Actively Recruiting
8
Blue Ridge Cancer Care ( Site 0144)
Roanoke, Virginia, United States, 24014
Actively Recruiting
9
Instituto Alexander Fleming ( Site 0311)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
Actively Recruiting
10
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0300)
Mar del Plata, Buenos Aires, Argentina, B7600FZO
Actively Recruiting
11
Hospital Italiano de Cordoba ( Site 0308)
Córdoba, Argentina, 5000
Actively Recruiting
12
CEMAIC ( Site 0309)
Córdoba, Argentina, X5008AAC
Actively Recruiting
13
Genesis Care- Campbelltown ( Site 2907)
Campbelltown, New South Wales, Australia, 2560
Actively Recruiting
14
Northern Beaches Hospital ( Site 2905)
Frenchs Forest, New South Wales, Australia, 2086
Actively Recruiting
15
The Prince Charles Hospital ( Site 2903)
Brisbane, Queensland, Australia, 4032
Actively Recruiting
16
Mater Hospital Brisbane ( Site 2906)
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
17
Klinikum Klagenfurt am Wörthersee ( Site 1002)
Klagenfurt, Carinthia, Austria, 9020
Actively Recruiting
18
Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 1005)
Graz, Styria, Austria, 8036
Actively Recruiting
19
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1001)
Vienna, Austria, 1210
Actively Recruiting
20
Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3903)
Genk, Limburg, Belgium, 3600
Actively Recruiting
21
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0412)
Fortaleza, Ceará, Brazil, 60336-232
Actively Recruiting
22
Hospital Santa Rita de Cassia ( Site 0403)
Vitória, Espírito Santo, Brazil, 29043-260
Actively Recruiting
23
Real Hospital Portugues ( Site 0418)
Recife, Pernambuco, Brazil, 52010075
Actively Recruiting
24
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa ( Site 0400)
Porto Alegre, Rio Grande do Sul, Brazil, 90110-270
Actively Recruiting
25
CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0410)
Florianópolis, Santa Catarina, Brazil, 88020-210
Actively Recruiting
26
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto USP ( Site 0419)
Ribeirão Preto, São Paulo, Brazil, 14048-900
Actively Recruiting
27
Faculdade de Medicina do ABC ( Site 0411)
Santo André, São Paulo, Brazil, 09060-870
Actively Recruiting
28
Hospital Alemao Oswaldo Cruz ( Site 0413)
São Paulo, São Paulo, Brazil, 01327-001
Actively Recruiting
29
IBCC - Núcleo de Pesquisa e Ensino ( Site 0417)
São Paulo, Brazil, 04014-002
Actively Recruiting
30
Centro de Estudios Clínicos SAGA ( Site 0503)
Santiago, Region M. de Santiago, Chile, 7500653
Actively Recruiting
31
FALP ( Site 0500)
Santiago, Region M. de Santiago, Chile, 7500921
Actively Recruiting
32
Bradfordhill ( Site 0501)
Santiago, Region M. de Santiago, Chile, 8420383
Actively Recruiting
33
Anhui Provincial Cancer Hospital ( Site 2708)
Hefei, Anhui, China, 230031
Actively Recruiting
34
Beijing Cancer hospital-Thoracic Cancer Department A ( Site 2700)
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
35
Beijing Peking Union Medical College Hospital ( Site 2702)
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
36
The First Affiliated Hospital of Fujian Medical University ( Site 2701)
Fujian, Fujian, China, 350005
Actively Recruiting
37
Fujian Provincial Cancer Hospital ( Site 2706)
Fuzhou, Fujian, China, 350014
Actively Recruiting
38
The First Affiliated Hospital of Xiamen University ( Site 2717)
Fuzhou, Fujian, China, 361003
Actively Recruiting
39
The First Affiliated Hospital.Sun Yat-sen University ( Site 2714)
Guangzhou, Guangdong, China, 510080
Actively Recruiting
40
AFFILIATED CANCER HOSPITAL AND INSTITUTE OF GUANGZHOU MEDICAL UNIVERSITY ( Site 2743)
Guangzhou, Guangdong, China, 510095
Actively Recruiting
41
Zhujiang Hospital of Southern Medical University ( Site 2744)
Guangzhou, Guangdong, China, 510280
Actively Recruiting
42
Affiliated Cancer Hospital of Guangxi Medical University ( Site 2704)
Nanning, Guangxi, China, 530021
Actively Recruiting
43
JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 2745)
Jiamusi, Heilongjiang, China, 154007
Actively Recruiting
44
Henan Cancer Hospital ( Site 2746)
Zhengzhou, Henan, China, 450008
Actively Recruiting
45
Tongji Hospital Tongji Medical,Science & Technology ( Site 2722)
Wuhan, Hubei, China, 430030
Actively Recruiting
46
Hubei Cancer Hospital ( Site 2721)
Wuhan, Hubei, China, 430079
Actively Recruiting
47
Xiangya Hospital Central South University ( Site 2741)
Changsha, Hunan, China, 410008
Actively Recruiting
48
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 2715)
Nanjing, Jiangsu, China, 210000
Active, Not Recruiting
49
Jiangxi Cancer Hospital ( Site 2725)
Nanchang, Jiangxi, China, 330029
Actively Recruiting
50
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 2729)
Xi'an, Shaanxi, China, 710061
Actively Recruiting
51
LinYi Cancer Hospital ( Site 2737)
Linyi, Shandong, China, 276000
Actively Recruiting
52
Shanghai Pulmonary Hospital-Oncology Department ( Site 2723)
Shanghai, Shanghai Municipality, China, 200433
Actively Recruiting
53
Shanxi Cancer Hospital ( Site 2728)
Taiyuan, Shanxi, China, 030013
Actively Recruiting
54
Sichuan Cancer Hospital. ( Site 2739)
Chengdu, Sichuan, China, 610213
Actively Recruiting
55
West China Hospital Sichuan University ( Site 2735)
Chengdu, Sichuan, China, 611135
Actively Recruiting
56
Chongqing University Cancer Hospital ( Site 2736)
Chongqing, Sichuan, China, 400030
Actively Recruiting
57
Yunnan Province Cancer Hospital ( Site 2734)
Kunming, Yunnan, China, 650118
Actively Recruiting
58
The First Affiliated Hospital, Zhejiang University ( Site 2716)
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
59
Sir Run Run Shaw Hospital ( Site 2731)
Hangzhou, Zhejiang, China, 310015
Actively Recruiting
60
Zhejiang Cancer Hospital ( Site 2727)
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
61
Taizhou Hospital of Zhejiang Province-Respiratory ( Site 2724)
Taizhou, Zhejiang, China, 317000
Actively Recruiting
62
Hopital Europeen Marseille ( Site 1207)
Marseille, Bouches-du-Rhone, France, 13003
Actively Recruiting
63
CHU Caen ( Site 1212)
Caen, Calvados, France, 14000
Actively Recruiting
64
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 1209)
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France, 54500
Actively Recruiting
65
Centre Hospitalier Metropole Savoie Site de Chambery ( Site 1208)
Chambéry, Savoie, France, 73011
Actively Recruiting
66
Clinique de l'Europe ( Site 1213)
Amiens, Somme, France, 80000
Actively Recruiting
67
Groupe Hospitalier Paris Saint Joseph ( Site 1215)
Paris, France, 75014
Actively Recruiting
68
Hôpital Européen Georges Pompidou ( Site 1214)
Paris, France, 75015
Actively Recruiting
69
Agios Andreas Hospital Patras ( Site 1407)
Pátrai, Achaia, Greece, 263 35
Actively Recruiting
70
Errikos Dunant Hospital Center ( Site 1408)
Athens, Attica, Greece, 115 26
Actively Recruiting
71
General Hospital of Athens "Laiko" ( Site 1402)
Athens, Attica, Greece, 11526
Actively Recruiting
72
Metropolitan General Hospital ( Site 1400)
Athens, Attica, Greece, 155 62
Actively Recruiting
73
Papageorgiou General Hospital of Thessaloniki ( Site 1403)
Thessaloniki, Greece, 564 29
Actively Recruiting
74
Orszagos Koranyi Pulmonologiai Intezet ( Site 1501)
Budapest, Pest County, Hungary, 1121
Actively Recruiting
75
Reformatus Pulmonologiai Centrum ( Site 1503)
Törökbálint, Pest County, Hungary, 2045
Actively Recruiting
76
Yitzhak Shamir Medical Center. ( Site 1709)
Beer Ya Akov, Israel, 7033001
Actively Recruiting
77
Shaare Zedek Medical Center ( Site 1706)
Jerusalem, Israel, 9103102
Actively Recruiting
78
Meir Medical Center. ( Site 1702)
Kfar Saba, Israel, 4428164
Actively Recruiting
79
Sheba Medical Center ( Site 1700)
Ramat Gan, Israel, 5265601
Actively Recruiting
80
Sourasky Medical Center ( Site 1705)
Tel Aviv, Israel, 6423906
Actively Recruiting
81
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1807)
Meldola, Forli-Cesena, Italy, 47014
Actively Recruiting
82
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 1811)
Bergamo, Lombardy, Italy, 24127
Actively Recruiting
83
Istituto Clinico Humanitas ( Site 1812)
Rozzano, Milano, Italy, 20089
Actively Recruiting
84
Ospedale San Giuseppe Moscati ( Site 1816)
Statte, Taranto, Italy, 74010
Actively Recruiting
85
AOU Careggi ( Site 1801)
Florence, Tuscany, Italy, 50134
Actively Recruiting
86
AOU Renato Dulbecco ( Site 1804)
Catanzaro, Italy, 88100
Actively Recruiting
87
A.O.R.N. Antonio Cardarelli ( Site 1810)
Naples, Italy, 80131
Actively Recruiting
88
Policlinico San Matteo ( Site 1802)
Pavia, Italy, 27100
Actively Recruiting
89
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 1809)
Verona, Italy, 37126
Actively Recruiting
90
Aichi Cancer Center ( Site 2813)
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
91
Fujita Health University Hospital ( Site 2807)
Toyoake, Aichi-ken, Japan, 470-1192
Actively Recruiting
92
Hirosaki University Hospital ( Site 2818)
Hirosaki, Aomori, Japan, 036-8563
Actively Recruiting
93
National Hospital Organization Himeji Medical Center ( Site 2827)
Himeji, Hyōgo, Japan, 670-8520
Actively Recruiting
94
Kobe City Medical Center General Hospital ( Site 2811)
Kobe, Hyōgo, Japan, 650-0047
Actively Recruiting
95
Takarazuka City Hospital ( Site 2828)
Takarazuka, Hyōgo, Japan, 665-0827
Actively Recruiting
96
Yokohama Municipal Citizen's Hospital ( Site 2824)
Yokohama, Kanagawa, Japan, 221-0855
Actively Recruiting
97
Kanagawa Cancer Center ( Site 2820)
Yokohama, Kanagawa, Japan, 241-8515
Actively Recruiting
98
Saiseikai Matsusaka Municipal Hospital ( Site 2808)
Matsusaka, Mie-ken, Japan, 515-8544
Actively Recruiting
99
Tohoku University Hospital ( Site 2804)
Sendai, Miyagi, Japan, 980-8574
Actively Recruiting
100
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 2822)
Sakai, Osaka, Japan, 591-8555
Actively Recruiting
101
Osaka Medical and Pharmaceutical University Hospital ( Site 2810)
Takatsuki, Osaka, Japan, 569-8686
Actively Recruiting
102
National Hospital Organization Ureshino Medical Center ( Site 2817)
Ureshino, Saga-ken, Japan, 843-0393
Actively Recruiting
103
Nippon Medical School Hospital ( Site 2819)
Bunkyo, Tokyo, Japan, 113-8603
Actively Recruiting
104
Tokyo Medical University Hospital ( Site 2829)
Shinjuku, Tokyo, Japan, 160-0023
Actively Recruiting
105
National Center for Global Health and Medicine ( Site 2806)
Shinjuku, Tokyo, Japan, 162-8655
Actively Recruiting
106
Chiba University Hospital ( Site 2812)
Chiba, Japan, 260-8677
Actively Recruiting
107
National Hospital Organization Kyushu Medical Center ( Site 2801)
Fukuoka, Japan, 810-8563
Actively Recruiting
108
Hiroshima City Hiroshima Citizens Hospital ( Site 2821)
Hiroshima, Japan, 730-8518
Actively Recruiting
109
Saiseikai Kumamoto Hospital ( Site 2816)
Kumamoto, Japan, 861-4193
Actively Recruiting
110
Osaka Metropolitan University Hospital ( Site 2826)
Osaka, Japan, 545-8586
Actively Recruiting
111
Hospital Tengku Ampuan Afzan ( Site 3109)
Kuantan, Pahang, Malaysia, 25100
Actively Recruiting
112
Hospital Pulau Pinang ( Site 3108)
George Town, Pulau Pinang, Malaysia, 10990
Actively Recruiting
113
Hospital Wanita and Kanak Kanak Sabah ( Site 3110)
Kota Kinabalu, Sabah, Malaysia, 88996
Actively Recruiting
114
Sarawak General Hospital ( Site 3101)
Kuching, Sarawak, Malaysia, 93586
Actively Recruiting
115
Sunway Medical Centre ( Site 3106)
Petaling Jaya, Selangor, Malaysia, 47500
Actively Recruiting
116
Amphia Ziekenhuis, locatie Breda Molengracht ( Site 1907)
Breda, North Brabant, Netherlands, 4818 CK
Actively Recruiting
117
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2008)
Przemyśl, Podkarpackie Voivodeship, Poland, 37-700
Actively Recruiting
118
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2012)
Gliwice, Silesian Voivodeship, Poland, 44-102
Actively Recruiting
119
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2004)
Olsztyn, Warmian-Masurian Voivodeship, Poland, 10-357
Actively Recruiting
120
Spitalul Clinic Colțea ( Site 2102)
Bucharest, Bucharest, Romania, 030171
Actively Recruiting
121
Institutul Oncologic Prof. Dr. I Chiricuta ( Site 2103)
Cluj-Napoca, Cluj, Romania, 400015
Actively Recruiting
122
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2101)
Florești, Cluj, Romania, 407280
Actively Recruiting
123
Centrul de Oncologie "Sfântul Nectarie" ( Site 2107)
Craiova, Dolj, Romania, 200347
Actively Recruiting
124
Spitalul Municipal Schuller Ploiești ( Site 2106)
Ploieşti, Prahova, Romania, 100337
Actively Recruiting
125
SC ONCO CARD SRL ( Site 2109)
Brasov, Romania, 500052
Actively Recruiting
126
SC MNT Healthcare Europe SRL ( Site 2105)
Bucharest, Romania, 013975
Actively Recruiting
127
Delta Health Care SRL ( Site 2108)
Bucharest, Romania, 014142
Actively Recruiting
128
Chonnam National University Hwasun Hospital ( Site 3502)
Jeollanam-do, Jeonranamdo, South Korea, 58128
Actively Recruiting
129
Pusan National University Yangsan Hospital ( Site 3504)
Yangsan, Kyongsangnam-do, South Korea, 50612
Actively Recruiting
130
Pusan National University Hospital ( Site 3501)
Busan, Pusan-Kwangyokshi, South Korea, 49241
Actively Recruiting
131
Chungnam National University Hospital ( Site 3503)
Daejeon, Taejon-Kwangyokshi, South Korea, 35015
Actively Recruiting
132
Kyung Hee University Medical Center ( Site 3500)
Seoul, South Korea, 02447
Actively Recruiting
133
Korea University Guro Hospital ( Site 3505)
Seoul, South Korea, 08308
Actively Recruiting
134
Institut Català d'Oncologia (ICO) - Badalona ( Site 2200)
Badalona, Catalonia, Spain, 08916
Actively Recruiting
135
HOSPITAL CLÍNIC DE BARCELONA ( Site 2201)
Barcelona, Catalonia, Spain, 08036
Actively Recruiting
136
Complejo Hospitalario Universitario A Coruna ( Site 2207)
A Coruña, La Coruna, Spain, 15006
Actively Recruiting
137
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2202)
Majadahonda, Madrid, Comunidad de, Spain, 28220
Actively Recruiting
138
Hospital General Universitario de Valencia ( Site 2204)
Valencia, Valenciana, Comunitat, Spain, 46014
Actively Recruiting
139
Hospital Universitario Ramon y Cajal ( Site 2203)
Madrid, Spain, 28034
Actively Recruiting
140
Hospital Universitario Virgen de Valme ( Site 2205)
Seville, Spain, 41014
Actively Recruiting
141
Chang Gung Memorial Hospital- Chiayi ( Site 3611)
Chiayi City, Chiayi, Taiwan, 613
Actively Recruiting
142
Taipei Medical University Shuang Ho Hospital ( Site 3602)
New Taipei City, Taiwan, 235
Actively Recruiting
143
National Cheng Kung University Hospital ( Site 3604)
Tainan, Taiwan, 704
Actively Recruiting
144
MacKay Memorial Hospital ( Site 3609)
Taipei, Taiwan, 10449
Actively Recruiting
145
Tri-Service General Hospital ( Site 3603)
Taipei, Taiwan, 114
Actively Recruiting
146
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2504)
Chernivtsi, Chernivetska Oblast, Ukraine, 58013
Actively Recruiting
147
Communal noncommercial enterprise of Lviv regional council "Lviv oncological regional therapeutical ( Site 2507)
Lviv, Lviv Oblast, Ukraine, 79031
Actively Recruiting
148
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2517)
Rivne, Rivne Oblast, Ukraine, 33010
Actively Recruiting
149
Shalimov Institute of Surgery and Transplantation Oncology department ( Site 2512)
Kyiv, Ukraine, 02000
Actively Recruiting
150
Universal Clinic Oberig ( Site 2506)
Kyiv, Ukraine, 03057
Actively Recruiting
151
Royal Cornwall Hospital ( Site 2614)
Truro, Cornwall, United Kingdom, TR1 2LJ
Actively Recruiting
152
Royal Free Hospital ( Site 2601)
London, London, City of, United Kingdom, NW3 2QG
Actively Recruiting
153
Leicester Royal Infirmary ( Site 2610)
Leicester, United Kingdom, LE1 5WW
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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