Clinical Testing and Assessment of the Physiological Effects of Invasive Spinal Cord Stimulation Using Electroencephalography to Optimize Rehabilitation Programs and Develop Personalized Approaches for Recovery After Spinal Injury

What this Trial Is About

This research aims to understand brain network problems and how they recover during rehabilitation with spinal cord stimulation (SCS) in people with spinal cord injuries. It focuses on recording resting-state EEG to track brain function changes and explore how brain neuroplasticity plays a role when effective SCS programs are used with implanted electrodes. The study includes participants with either partial or complete spinal cord injuries at various levels. Participants first have resting-state EEG recordings before and after implanting multichannel electrodes into the epidural space below the injury. The spinal cord stimulator is then activated, and optimal stimulation programs are selected to either reduce spasticity or improve voluntary muscle control. Throughout the rehabilitation, EEG recordings are taken before, during, and after stimulation, including a final recording before discharge. The stimulation parameters are adjusted systematically over about two weeks to maximize effectiveness and comfort. During the study, participants follow motor imagery exercises imagining and then performing limb movements while EEG is recorded with the stimulator both off and on. Researchers monitor changes in EEG rhythms and connectivity, focusing on measures like mu rhythm desynchronization. The study also uses clinical scales for neurological function and quality of life at baseline. Postoperative monitoring continues for up to two weeks to ensure safety and track progress. The collected data aims to improve rehabilitation strategies and personalize recovery after spinal cord injury.

Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography