Collection of Biological Samples to Study Autoimmune, Dysimmune, and Auto-inflammatory Skin Diseases Including Bullous Dermatoses and Systemic Autoimmune Conditions

What this Trial Is About

This research aims to collect biological and clinical data from patients with autoimmune, dysimmune, or auto-inflammatory skin diseases. These conditions include a wide range of rare diseases that collectively affect a significant portion of the adult population, especially women. The study focuses on understanding the breakdown of self-tolerance and the complex mechanisms behind these diseases, as well as identifying patient subgroups based on clinical and biological profiles to improve diagnosis and treatment. Participants will provide biological samples such as blood, cerebrospinal fluid, saliva, stools, urine, tissue biopsies, and hair follicles during their normal diagnostic and follow-up care. The study will gather these samples and clinical data over an average period of one year. The goal is to build a collection that supports the identification of new autoantibodies, biomarkers related to disease severity, and the exploration of disease mechanisms. Samples will also be analyzed to compare blood cell populations before and after certain therapies. During the study, participants will be involved in providing biological specimens as part of their routine medical care. Researchers will monitor these samples and clinical data to assess disease markers, treatment responses, and underlying disease processes. The main outcome is the development of a detailed biological and clinical collection to support future research and therapeutic strategies. The study follows participants for about one year, with ongoing data collection throughout this period.

Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases